Measured by the ability of the immobilized protein to support the adhesion of FaDu human squamous cell carcinoma cells. When 5 x 10^4 cells per well are added to rmCHI3-L1 coated plate, cell adhesion is enhanced in a dose dependent manner after 30 minutes at 37 °C. The ED50 for this effect is 0.8-3.2 μg/mL. Optimal concentrations should be determined by each laboratory for each application.
Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.
规格
产品名称
Recombinant Mouse Chitinase 3-like 1/YKL-40 Protein
别名
软骨糖蛋白39(CHI3L1)重组蛋白
英文别名
AW208766 | Brp39 | CHI3L1 | Chitinase 3 like 1 | Chitinase 3-like 1 | gp39 | HCgp39 | YKL-40 | Chil1 | chitinase 3 like 1 (cartilage glycoprotein 39) | Chitinase 3 like protein 1 precursor | Chitinase-3-like protein 1 | Chondrocyte protein YKL40
Measured by the ability of the immobilized protein to support the adhesion of FaDu human squamous cell carcinoma cells. When 5 x 10^4 cells per well are added to rmCHI3-L1 coated plate, cell adhesion is enhanced in a dose dependent manner after 30 minutes at 37 °C. The ED50 for this effect is 0.8-3.2 μg/mL. Optimal concentrations should be determined by each laboratory for each application.
Lyophilized from 10mM PBS, 5% Trehalose, 5% Mannitol, pH 7.4
复溶
Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
在 -20~-80℃ 下可保存 1 年以上。复溶后建议分装。避免冷冻/解冻循环。
图片
Recombinant Mouse Chitinase 3-like 1/YKL-40 Protein (rp167402) - SDS-PAGE 2 μg/lane of Recombinant Mouse Chitinase 3-like 1/YKL-40 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 41 kDa.
ZJ25F0521944
危险品化学品经营许可证（带存储）