Purity ≥95% (SDS-PAGE) Endotoxin level <0.1 EU/μg Function GFR alpha -like (GDNF receptor-alpha-like) is a distant member of the GDNFR family of proteins. Mature human GFR alpha-like is a 376 amino acid (aa) type I transmembrane protein. It contains a 333 aa extracellular domain, a 20 aa transmembrane domain and a 23 aa cytoplasmic domain. Over the extracellular domain, human GFRAL shares 72% and 71% identity with mouse and rat GFRAL respectively. GFRAL is expressed on both fetal and adult hindbrain neurons of the CNS, and would appear to function as an anti-apoptotic molecule during neuronal stress. GFRAL is a functional receptor for GDF-15, facilitating weight-loss functions of the protein through c-Ret downstream signaling. GFRAL and GDF-15 signaling is implicated in diet-based obesity and insulin resistance.
规格
产品名称
Recombinant Human GFR alpha-like Protein
别名
重组人GFRAL蛋白 | 重组人 GFR alpha 样蛋白
英文别名
GFR alpha like | GFR alpha-like | GFRAL | GRAL | UNQ9356 | C6orf144 | bA360D14.1
40.0 - 50.0 kDa, under reducing conditions; 40.0 - 50.0 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from 10mM PBS, 5% Trehalose, 5% Mannitol, pH 7.4
复溶
Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
在 -20~-80℃ 下可保存 1 年以上。收货后建议分装。避免冷冻/解冻循环。
图片
Recombinant Human GFR alpha-like Protein (rp167646) - Protein Bioactivity Immobilized Recombinant Human GFR alpha-like Protein (rp167646) at 0.5 μg/mL can bind Human GDF15 with the EC
₅₀
of 8.5 ng/mL.
Recombinant Human GFR alpha-like Protein (rp167646) - SDS-PAGE 3 μg/lane of Recombinant Human GFR alpha-like Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 40.0 - 50.0 kDa.