Measured by its ability to neutralize Activin-mediated erythroid differentiation of K562 human chronic myelogenous leukemia cells. The ED50 for this effect is 3-15 ng/mL in the presence of 7.5 ng/mL recombinant human Activin A.
Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.
规格
产品名称
Recombinant Human FLRG Protein
别名
卵泡抑素样蛋白3(FSTL3)重组蛋白
英文别名
FLRGFSRP | FLRG | follistatin-like 3 (secreted glycoprotein) | Follistatin-like 3 | Follistatin-like protein 3 | Follistatin-related gene protein | follistatin-related protein 3 | FSTL3 | FSRP
Measured by its ability to neutralize Activin-mediated erythroid differentiation of K562 human chronic myelogenous leukemia cells. The ED50 for this effect is 3-15 ng/mL in the presence of 7.5 ng/mL recombinant human Activin A.
35 kDa, under reducing conditions; 33 & 60 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from 10mM PBS, 5% Trehalose, 5% Mannitol, pH 7.4
复溶
Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
在 -20~-80℃ 下可保存 1 年以上。收货后建议分装。避免冷冻/解冻循环。
图片
Recombinant Human FLRG Protein (rp168695) - SDS-PAGE 2 μg/lane of Recombinant Human FLRG Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 35 kDa under reducing condition and 33 & 60 kDa under non-reducing condition.
ZJ25F0319882
危险品化学品经营许可证（带存储）