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224,000+ 科研产品 · 三重ISO认证 · 每个产品均提供COA和SDS · 现货产品当日发货

Recombinant Human Fas/TNFRSF6/CD95 Protein

货号: rp169551
COA
有货
级别和纯度: 无动物源 ? 无动物源（Animal Free）—— 不含动物源成分生产，降低污染风险。适用于避免动物源材料的生物制造和培养。 无载体 ? 无载体（Carrier Free）—— 不含添加的载体蛋白/稳定剂。当载体（如 BSA）会干扰偶联或敏感检测时使用。 生物活性 ? 生物活性级（Bioactive）—— 经验证在功能检测中保持生物活性。当分子须具有功能活性而不仅是纯度时使用。 ActiBioPure™ ? ActiBioPure™ —— 阿拉丁面向生物活性和重组产品的优质系列。当同时需要高纯度和保持生物活性时使用。 His标签 ? 组氨酸(His) 标签级 —— 带有 His 标签的重组蛋白，供亲和纯化/检测。用于纯化、固定或检测带标签蛋白。 PBS Only ? 仅 PBS 配方 —— 以磷酸盐缓冲液供应，不含其他添加剂。当需要不含稳定剂/载体的洁净 PBS 缓冲液时使用。 ≥95%(SDS-PAGE)
Accession #
P25445
蛋白标签
C-His
表达系统
HEK293
内毒素水平
<1.0 EU/μg
生物活性
Immobilized Recombinant Human Fas/TNFRSF6/CD95 Protein (rp169551) at 1.0 μg/mL can bind Fas Antibody (Ab102968) with the EC50 of 199.2 ng/mL.
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规格
库存
价格
数量
10μg
rp169551-10μg
现货 Stock Image
¥519.90
50μg
rp169551-50μg
现货 Stock Image
¥1,539.90
100μg
rp169551-100μg
现货 Stock Image
¥2,469.90
1mg
rp169551-1mg
期货 Stock Image
¥13,299.90
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大包装 / 定制
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SDS
安全数据
COA
分析证书
Data Sheet
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Spec Sheet
规格说明
大包装询价 收藏夹
Recombinant Human Fas/TNFRSF6/CD95 Protein
规格 储存与运输 图片 技术文档 高级数据 质检证书（CoA,COO,BSE/TSE 和分析图谱) 技术文档和文章 溶液计算器
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为什么选择此级别

ActiBioPure™,His标签,PBS Only,无动物源,无载体,生物活性 级 提供 ≥95%(SDS-PAGE) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。

🌡

储存与运输

-20°C储存,避免反复冻融。超低温运输 。请查阅批次 COA 获取详细规格。

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质量文档

SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。

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文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。

规格

产品名称
Recombinant Human Fas/TNFRSF6/CD95 Protein
别名
重组人Fas/TNFRSF6/CD95蛋白 | 重组人凋亡相关因子蛋白 | 肿瘤坏死因子受体超家族成员6
英文别名
Apo-1 antigen | Apo-1 | apoptosis antigen 1 | Apoptosis-mediating surface antigen FAS | APT1 | APT1FASTM | CD95 antigen | CD95 | CD95ALPS1A | Fas (TNF receptor superfamily | Fas AMA | Fas antigen | Fas | FAS1 | FASLG receptor | TNFRSF6 | TNFRSF6member 6 |
规格或纯度
无动物源,无载体,生物活性,ActiBioPure™,His标签,PBS Only,≥95%(SDS-PAGE)
生化机理
CD95 (APO-1/Fas) is an important inducer of the extrinsic apoptosis signaling pathway and therapy induced apoptosis of many tumor cells has been linked to the activity of CD95. is a prototype death receptor characterized by the presence of an 80 amino acid death domain in its cytoplasmic tail. This domain is essential for the recruitment of a number of signaling components upon activation by either agonistic anti-CD95 antibodies or cognate CD95 ligand that initiate apoptosis. The complex of proteins that forms upon triggering of CD95 is called the death-inducting signaling complex (DISC). The DISC consists of an adaptor protein and initiator caspases and is essential for induction of apoptosis. CD95 is also crucial for the negative selection of B cells within the germinal center (GC). Impairment of CD95-mediated apoptosis results in defective affinity maturation and the persistence of autoreactive B-cell clones. Changes in the expression of CD95 and/or its ligand CD95L are frequently found in human cancer. The downregulation or mutation of CD95 has been proposed as a mechanism by which cancer cells avoid destruction by the immune system through reduced apoptosis sensitivity. Thus, CD95 has therefore been viewed as a tumor suppressor. CD95 has been reported to be involved in the activation of NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and the alternate pathways for CTL-mediated cytotoxicity. Accordingly, this protein is implicated in the pathogenesis of various malignancies and diseases of the immune system. The CD95/CD95L system was implicated in the etiology of inflammatory bowel disease (IBD) based, primarily, on the finding that CD95 is highly expressed in the intestinal epithelial cells and that epithelial apoptosis is increased in IBD. Post-translational: (Microbial infection) Glycosylated at Arg-250 by enteropathogenic E.coli protein NleB1: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions. Palmitoylated. Palmitoylation by ZDHHC7 prevents the lysosomal degradation of FAS regulating its expression at the plasma membrane. N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
生物活性
Immobilized Recombinant Human Fas/TNFRSF6/CD95 Protein (rp169551) at 1.0 μg/mL can bind Fas Antibody (Ab102968) with the EC50 of 199.2 ng/mL.
表达系统
HEK293
种属
人(Human)
氨基酸
26-173 aa
序列
QVTDINSKGLELRKTVTTVETQNLEGLHHDGQFCHKPCPPGERKARDCTVNGDEPDCVPCQEGKEYTDKAHFSSKCRRCRLCDEGHGLEVEINCTRTQNTKCRCKPNFFCNSTVCEHCDPCTKCEHGIIKECTLTSNTKCKEEGSRSNHHHHHH
蛋白标签
C-His
无载体
Yes
无动物源
Yes
来源
重组表达
预测分子量
17.5 kDa.
SDS-PAGE
22.7-39.5 kDa, under reducing conditions; 19.9-39.5 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from PBS, pH 7.4.
复溶
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
Store at -20°C for 1 year. Avoid freeze/thaw cycle.
图片

Recombinant Human Fas/TNFRSF6/CD95 Protein (rp169551) - ELISA
Immobilized Recombinant Human Fas/TNFRSF6/CD95 Protein (rp169551) at 1.0 μg/mL can bind Fas Antibody (Ab102968) with the EC50 of 199.2 ng/mL.

Recombinant Human Fas/TNFRSF6/CD95 Protein (rp169551) - SDS-PAGE
3 μg/lane of Recombinant Human Fas/TNFRSF6/CD95 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 22.7-39.5 kDa under reducing conditions and 19.9-39.5 kDa under non-reducing conditions.

技术文档

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高级数据

质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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找到3个结果

批号(Lot Number) 证书类型 货号
ZJ25F0116989 分析证书 rp169551
ZJ25F0116990 分析证书 rp169551
ZJ25F0116991 分析证书 rp169551
技术文档和文章
鞘脂代谢重塑在凋亡与炎症信号中的作用
目录： 技术文章
探索主题:
Fas 神经酰胺 鞘脂代谢 TRAIL TNFα NLRP3 凋亡 炎症信号
Role of Sphingolipid Metabolic Remodeling in Apoptotic and Inflammatory Signaling
目录： 技术文章
探索主题:
Apoptosis Fas Ceramide TRAIL NLRP3 sphingolipid metabolism TNFalpha inflammatory signaling
Fas通路的分子机制与生物学功能
目录： 技术文章
探索主题:
Fas CD95 FasL 死亡受体 FADD Caspase-8 DISC 外源性凋亡
Molecular Mechanisms and Biological Functions of the Fas Pathway
目录： 技术文章
探索主题:
Fas CD95 FasL FADD Caspase-8 DISC Death receptor Extrinsic apoptosis
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