Protein Function:: The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also known as CD16a, encodes a transmembrane protein expressed on activated monocytes/macrophages, natural killer (NK) cells, and a subset of T cells. CD16a / FCGR3A is a receptor expressed on NK cells that facilitates antibody dependent cellular cytotoxicity (ADCC) by binding to the Fc portion of various antibodies. CD16a / FCGR3A also has a broader function. CD16a / FCGR3A is directly involved in the lysis of some virus-infected cells and tumor cells by NK cells, independent of antibody binding. Cross-linking of CD16a / FCGR3A on NK cells resulted in increased intracellular Ca2+ levels and a cascade of biochemical events similar to those activated by the T cell receptor. CD16a / FCGR3A on human NK cells is a lysis receptor that mediates the direct killing of some virus infected and tumor cells, independent of antibody ligation.
规格
产品名称
Recombinant Human Fc gamma RIIIA/CD16a Protein
别名
重组人Fc gamma RIIIA/CD16a蛋白 | 重组人 FcγRIIIA/CD16a 蛋白
英文别名
CD16a | CD16FCRIIIA | Fc fragment of IgG, low affinity IIIa, receptor (CD16a) | Fc fragment of IgG, low affinity IIIa, receptor for (CD16) | Fc gamma receptor III-A | Fc gamma RIIIA | FCG3 | Fc-gamma receptor III-2 (CD 16) | Fc-gamma receptor IIIb (CD16)
35.0-55.0 kDa, under reducing conditions; 35.0-55.0 kDa, under non-reducing conditions
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from PBS, pH 7.4
复溶
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
在 -20°C 下可保存 1 年。避免冷冻/解冻循环。
图片
Recombinant Human Fc gamma RIIIA/CD16a Protein (rp169611) - SDS-PAGE 3 μg/lane of Recombinant Human Fc gamma RIIIA/CD16a Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 35.0-55.0 kDa.