Protein Function: IGFBP-2, also known as IGFBP2, is an insulin-like growth factor-binding protein (IGFBP). IGFBPs prolong the half-life of the IGFs, control bioavailability, activity, and distribution of insulin-like growth factor (IGF) through high-affinity IGFBP/IGF complexes. Six high-affinity IGF-binding proteins (IGFBP-1 to -6) have been identified. The six IGFBPs are structurally related but encoded by distinct genes. IGFBPs have a high affinity for IGFs. Some members of the IGFBP family have been consistently shown to inhibit IGF actions by preventing them from gaining access to the IGF receptors, while others potentiate IGF actions by facilitating the ligand-receptor interaction. IGFBP-2 is overexpressed in many malignancies and is often correlated with an increasingly malignant status of the tumor, pointing to the potential involvement of IGFBP-2 in tumorigenesis. It contains 1 IGFBP N-terminal domain and 1 thyroglobulin type-1 domain. It inhibits IGF-mediated growth and developmental rates.
规格
产品名称
Recombinant Human IGFBP-2 Protein
别名
重组人IGFBP-2蛋白 | 重组人类 IGFBP-2 蛋白
英文别名
IBP2 | IBP-2 | IGF-binding protein 2 | IGFBP2 | IGFBP-2 | IGF-BP53 | insulin-like growth factor binding protein 2 (36kD) | insulin-like growth factor binding protein 2, 36kDa | insulin-like growth factor-binding protein 2 | BP2
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
在 -20°C 下可保存 1 年。避免冷冻/解冻循环。
图片
Recombinant Human IGFBP-2 Protein (rp169617) - Binding Activity Immobilized Recombinant Human IGFBP-2 Protein (rp169617) at 2.0 μg/mL can bind Recombinant Human IGF-1 Protein (Ab147252) with the EC50 of 113.7 ng/mL.
Recombinant Human IGFBP-2 Protein (rp169617) - SDS-PAGE 2 μg/lane of Recombinant Human IGFBP-2 Protein was resolved with SDS-PAGE under reducing (R) conditions and visualized by Coomassie® Blue staining, showing a band at 33.3 kDa.