Purity:>95%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description: Thymic stromal lymphopoietin (TSLP) is an interleukin 7 (IL-7)-like cytokine originally characterized by its ability to promote the activation of B cells and dendritic cells (DCs). Thymic stromal lymphopoietin (TSLP) is a cytokine expressed by epithelial cells, including keratinocytes, and is important in allergic inflammation. Subsequent studies have shown that TSLP promotes T helper type 2 (TH2) cell responses associated with immunity to some helminth parasites and the pathogenesis of many inflammatory diseases, including atopic dermatitis and asthma. TSLP can promote TH2 cytokine-associated inflammation by directly promoting the effector functions of CD4+ TH2 cells, basophils and other granulocyte populations while simultaneously limiting the expression of DC-derived proinflammatory cytokines and promoting regulatory T cell responses in peripheral tissues.
规格
产品名称
Recombinant Human TSLP Protein
别名
重组人TSLP蛋白 | 重组人 TSLP 蛋白
英文别名
thymic stromal lymphopoietin | TSLP | Thymic stromal lymphopoietin protein TSLP | TSLP protein | TSLP_HUMAN | EC 1.3.5.1 | Ip | Iron-sulfur subunit of complex II
规格或纯度
无载体,生物活性,ActiBioPure™,无叠氮钠,His标签,≥95%(SDS-PAGE)
生物活性
Immobilized Recombinant Human TSLP Protein (rp169653) at 2.0 μg/mL can bind Tezepelumab (anti-TSLP) (Ab170833) with the EC50 of 18.04 ng/mL.
Lyophilized from PBS, 2.5%Glycerol, 1mM EDTA, pH7.4
复溶
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 0.1 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
在 -20°C 下可保存 1 年。避免冷冻/解冻循环。
图片
Recombinant Human TSLP Protein (rp169653) - SDS-PAGE Recombinant Human TSLP Protein was resolved with SDS-PAGE under reducing (R) conditions and visualized by Coomassie® Blue staining, showing a band at 15.4 kDa.
Recombinant Human TSLP Protein (rp169653) - ELISA Immobilized Recombinant Human TSLP Protein (rp169653) at 2.0 μg/mL can bind Tezepelumab (anti-TSLP) (Ab170833) with the EC₅₀ of 18.04 ng/mL.