Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor (PubMed:35767951). Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation.
Post-translational: Heavily N- and O-glycosylated.
生物活性
Immobilized Recombinant Human CD45 Protein (rp169658) at 1.0 μg/mL can bind CD45 Mouse mAb (Ab094902) with the EC50 of 65.4 ng/mL.
131.4-171.2 kDa, under reducing conditions; 124.8-163.5 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from PBS, pH 7.4.
浓度
见COA
复溶
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 0.5 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
-20℃ 存储12个月;收货后建议分装,避免反复冻融。
图片
Recombinant Human CD45 Protein (rp169658) - ELISA Immobilized Recombinant Human CD45 Protein (rp169658) at 1.0 μg/mL can bind CD45 Mouse mAb (Ab094902) with the EC50 of 65.4 ng/mL.
Recombinant Human CD45 Protein (rp169658) - SDS-PAGE 3 μg/lane of Recombinant Human CD45 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 131.4-171.2 kDa under reducing conditions and 124.8-163.5 kDa under non-reducing conditions.