无载体,生物活性,ActiBioPure™,His标签,≥90%(SDS-PAGE),expressed in E. coli; 见COA
生化机理
Pro-inflammatory and angiogenic cytokine mainly secreted by monocytes and skin keratinocytes that plays crucial roles in immune responses, regulation of inflammatory responses, hemopoiesis, as well as epidermal cell and keratinocyte differentiation (PubMed:17277128, PubMed:34403503).
Enhances tissue remodeling and wound-healing activities and restores the homeostasis of epithelial layers during infection and inflammatory responses to maintain tissue integrity (PubMed:17277128).
Affects multiple actin-mediated functions in activated neutrophils leading to inhibition of phagocytosis, granule exocytosis, and migration (PubMed:28424238).
Exert its effects via the type I IL-20 receptor complex consisting of IL20RA and IL20RB (PubMed:11706020).
Alternatively, can mediate its activity through a second receptor complex called type II IL-20 receptor complex composed of IL22RA1 and IL20RB (PubMed:11564763).
Acts as an arteriogenic and vascular remodeling factory by activating a range of signaling processes including phosphorylations of JAK2 and STAT5 as well as activation of the serine and threonine kinases AKT and ERK1/2 (By similarity).
Alternatively, can activate STAT3 phosphorylation and transcriptional activity in a JAK2, ERK1/2 and p38 MAPK-dependent manner in keratinocytes (PubMed:23614738).
生物活性
Immobilized Recombinant Human IL-20 Protein (rp169664) at 1.0 μg/mL can bind Fletikumab (anti-IL-20) (Ab170642) with the EC50 of 187.2 ng/mL.
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 0.1 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
-20℃保存 12个月;复溶后建议分装,避免反复冻融。
图片
Recombinant Human IL-20 Protein (rp169664) - ELISA
Immobilized Recombinant Human IL-20 Protein (rp169664) at 1.0 μg/mL can bind Fletikumab (anti-IL-20) (Ab170642) with the EC₅₀ of 187.2 ng/mL.
Recombinant Human IL-20 Protein (rp169664) - SDS-PAGE
1 μg/lane of Recombinant Human IL-20 Protein was resolved with SDS-PAGE under reducing (R) and visualized by Coomassie® Blue staining, showing a band at 28.8 kDa under reducing conditions.