Fc标签,His标签,无动物源,无叠氮钠,无载体 级 提供 ≥90%(SDS-PAGE) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
-80℃储存,避免反复冻融。特低温运输 。请查阅批次 COA 获取详细规格。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
Purity
>90% SDS-PAGE.
Background:
Luteinizing Hormone (LH) is a 42 kDa heterodimer belonging to the glycoprotein hormone family. It is composed of noncovalently linked glycosylated alpha and beta chains. The alpha subunit (CG alpha ) is also a component of Follicle-Stimulating Hormone (FSH), Thyroid-Stimulating Hormone, and Chorionic Gonadotropin. The unique beta subunit confers the protein’s specific biological action and is responsible for the interaction with its receptor. The approximately 20 kDa human CG alpha subunit shares 73% and 72% amino acid (aa) sequence identity with the mouse and rat orthologs, respectively. The approximately 18 kDa human LH beta subunit shares 71% and 72% aa sequence identity with the mouse and rat orthologs, respectively. Multiple isoforms of LH exist due to differences in the post-translational glycosylation, sialylation, and sulphation modifications of its subunits. The composition, longevity, and activity of the different LH isoforms vary throughout a woman’s menstrual cycle and reproductive life cycle. LH is produced and secreted by the anterior pituitary gland. Its secretion is controlled by Gonadotropin-Releasing Hormone from the hypothalamus; however, LH secretion can also be stimulated by estradiol. LH works in concert with FSH to regulate female reproduction; FSH stimulates follicular growth and LH induces ovulation. LH also drives formation of the corpus luteum by promoting progesterone production. Additionally, LH has been suggested to stimulate the adrenal gland in postmenopausal women to induce secretion of sulfated DHEA, a precursor to androgens. In the testis, LH induces Leydig cell production of testosterone. Hypersecretion of LH has been shown to occur in women with polycystic ovary syndrome and is associated with an increased risk of infertility and miscarriage. Additionally, increased serum LH levels are associated with decreased cognition and have been implicated in the development and progression of Alzheimer’s disease. receptor into an A-frame.
Recombinant Human LH alpha/beta Heterodimer Protein (rp174456) - ELISA
Immobilized Recombinant Human LH alpha/beta Heterodimer Protein (rp174456) at 1.0 μg/mL can bind Luteinizing Hormone beta Antibody (Ab113728). The ED₅₀ for this effect is 85.08 ng/mL.
Recombinant Human LH alpha/beta Heterodimer Protein (rp174456) - SDS-PAGE
3 μg/lane of Recombinant Human LH alpha/beta Heterodimer Protein was resolved with SDS-PAGE under reducing (R) condition and visualized by Coomassie® Blue staining, showing a band at 64.3 kDa under reducing condition.
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 ZJ24F0506227 |
分析证书 | rp174456 |
| ZJ24F0506228 |
分析证书 | rp174456 |
| ZJ25F0218510 |
分析证书 | rp174456 |
| ZJ25F0218509 |
分析证书 | rp174456 |
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