LY3540378 is a a long-acting relaxin analogue [1]. It is composed a human relaxin mimetic peptide fused to a serum albumin-binding VHH domain. It is selective for relaxin family peptide receptor 1 (RXFP1) compared to RXFP2, 3 and 4. VHH-serum albumin binding extends the peptide's circulating half-life.
Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.
表达系统
CHO
种属
人(Human)
蛋白标签
No tag
来源
重组表达
预测分子量
21.8 kDa
作用类型
激动剂
作用机制
RXFP1 的激动剂
CAS编号和信息
rp174479
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
PBS
储存条件
-80℃储存,避免反复冻融
运输条件
特低温运输
稳定性与储存
储存在-80℃（3年）；收货后建议分装，避免反复冻融。
图片
LY3540378 (Volenrelaxin) (rp174479) - SDS-PAGE 2 μg/lane of LY3540378 (Volenrelaxin) (rp174479) was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 20 - 24 kDa.
ZJ25F0522088
危险品化学品经营许可证（带存储）