Pegvisomant is an approved drug (FDA (2003), EMA (2008))
Comment: Pegvisomant is a PEGylated 191 amino acid protein analogue of growth hormone, with antagonist action at the growth hormone receptor. The peptide sequence can be obtained via the ChEMBL link. PEGylation protects the peptide from proteolytic breakdown and extends its bioactive half-life.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Pegvisomant inhibits the ability of endogenous growth hormone to interact with the growth hormone receptor, the aim of which is to normalize serum IGF-I levels in acromegalic patients].
规格
产品名称
培维索孟, 生长激素受体拮抗剂
别名
培维索孟
英文别名
B2036-PEG | Somavert | B2036-PEG | Somavert
规格或纯度
重组,≥97%(SDS-PAGE),见COA.
生化机理
Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Circulating GH shows a great heterogeneity due to alternative splicing, differential post-translational modifications of monomeric forms, oligomerization, optional binding to 2 different GH-binding proteins, and potentially proteolytic processing.
表达系统
E. coli
种属
人(Human)
氨基酸
27-217 aa (H44D&H47N&G146K&R193N&K194A&D197S&K198R&E200S&I205T)
2 μg/lane of Pegvisomant was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 20 kDa under reducing conditions and 18 kDa under non-reducing conditions.
ZJ26F0232167
危险品化学品经营许可证（带存储）