Purity:>95%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description: High affinity immunoglobulin gamma Fc receptor I, also known as FCGR1 and CD64, is an integral membraneglycoprotein and a member of the immunoglobulin superfamily. CD64 is a high affinity receptor for the Fc region of IgG gamma and functions in both innate and adaptive immune responses. Receptors that recognize the Fc portion of IgG function in the regulation of immune response and are divided into three classes designated CD64, CD32, and CD16. CD64 is structurally composed of asignal peptidethat allows its transport to the surface of a cell, threeextracellularimmunoglobulin domainsof the C2-type that it uses to bind antibody, a hydrophobictransmembrane domain, and a short cytoplasmic tail. CD64 isconstitutivelyfound on only macrophages and monocytes, but treatment of polymorphonuclear leukocyteswith cytokines likeIFNγandG-CSFcan induce CD64 expression on these cells. The inactivation of the mouse CD64 resulted in a wide range of defects in antibody Fc-dependent functions. Mouse CD64 is an early participant in Fc-dependent cell activation and in the development of immune responses.
规格
产品名称
Recombinant Bovine CD64 Protein
别名
重组牛CD64蛋白 | 重组牛CD64蛋白
英文别名
CD64 antigen | CD64 | CD64a | Fc fragment of IgG, high affinity Ia, receptor (CD64) | Fc gamma RI | FCG1 | Fc-gamma receptor I B2 | Fc-gamma RI | Fc-gamma RIA | FcgammaRIa | FcgRI | FCGR1 | FcgRIA | FCRI | FcRIA | FLJ18345 | high affinity Ia, receptor for
37.7-52.3 kDa, under reducing conditions; 36.7-51.3 kDa, under non-reducing conditions
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from PBS, pH7.4
复溶
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 0.5 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
在 -20°C 下可保存 1 年。避免冷冻/解冻循环。
图片
Recombinant Bovine CD64 Protein (rp175924) - SDS-PAGE 3 μg/lane of Recombinant Bovine CD64 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 37.7-52.3 kDa under reducing conditions and 36.7-51.3 kDa under non-reducing conditions.