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Recombinant Human MMP-1 Protein (rp176239) - ELISA
Immobilized Recombinant Human MMP-1 Protein (rp176239) at 1.0 μg/mL can bind MMP1 Antibody (Ab115600) with the EC50 of 4.016 ng/mL.
ActiBioPure™,His标签,无动物源,无叠氮钠,无载体,生物活性 级 提供 ≥95%(SDS-PAGE) 纯度,适用于对基线干扰要求严格的色谱和分析工作流程。
-20°C储存,避免反复冻融。超低温运输 。请查阅批次 COA 获取详细规格。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
Purity: ≥95%, by SDS-PAGE visualized with Coomassie® Blue Staining.
Description:
MMP1, also known as MMP-1, contains 4 hemopexin-like domains and is a member of the matrix metalloproteinase (MMP) family. Matrix metalloproteases, also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and some bioactive molecules. MMP activity is regulated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell proliferation, migration, differentiation, angiogenesis, apoptosis, and host defenses. Dysregulation of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis, and cancer. Tumour metastasis is a multistep process involving the dissemination of tumor cells from the primary tumor to secondary at a distant organ or tissue. One of the first steps in metastasis is the degradation of the basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all have elevated expression in primary tumors and/or metastases. MMP-1 cleaves collagens of types I, II, and III at one site in the helical domain. It also cleaves collagens of types VII and X. In case of HIV infection, MMP1 interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.
Recombinant Human MMP-1 Protein (rp176239) - ELISA
Immobilized Recombinant Human MMP-1 Protein (rp176239) at 1.0 μg/mL can bind MMP1 Antibody (Ab115600) with the EC50 of 4.016 ng/mL.
Recombinant Human MMP-1 Protein (rp176239) - SDS-PAGE
3 μg/lane of Recombinant Human MMP-1 Protein was resolved with SDS-PAGE under reducing (R) and visualized by Coomassie® Blue staining, showing a band at 51.9-56.0 kDa.
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
| 分析证书 | rp176239 | |
| 分析证书 | rp176239 | |
| 分析证书 | rp176239 |
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