Recombinant Canis lupus CD19 Protein

货号: rp176268
有货
级别和纯度: 无动物源 ? 无动物源(Animal Free)—— 不含动物源成分生产,降低污染风险。适用于避免动物源材料的生物制造和培养。 无载体 ? 无载体(Carrier Free)—— 不含添加的载体蛋白/稳定剂。当载体(如 BSA)会干扰偶联或敏感检测时使用。 His标签 ? 组氨酸(His) 标签级 —— 带有 His 标签的重组蛋白,供亲和纯化/检测。用于纯化、固定或检测带标签蛋白。 Fc标签 ? Fc 标签级 —— 带有 Fc 标签的重组蛋白,供亲和纯化/检测。用于纯化、固定或检测带标签蛋白。Fc 标签有助于二聚化和 protein A/G 捕获。 PBS Only ? 仅 PBS 配方 —— 以磷酸盐缓冲液供应,不含其他添加剂。当需要不含稳定剂/载体的洁净 PBS 缓冲液时使用。 ≥90%(SDS-PAGE) 见COA
Accession #
A0A8C0PU30
蛋白标签
C-hFc & His
表达系统
CHO
内毒素水平
<1.0 EU/μg
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规格
库存
价格
数量
10μg
rp176268-10μg
现货 Stock Image
¥799.90
50μg
rp176268-50μg
现货 Stock Image
¥2,399.90
100μg
rp176268-100μg
现货 Stock Image
¥3,829.90
1mg
rp176268-1mg
期货 Stock Image
¥16,699.90
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为什么选择此级别

Fc标签,His标签,PBS Only,无动物源,无载体 级 提供 ≥90%(SDS-PAGE) 纯度,适用于对基线干扰要求严格的色谱和分析工作流程。

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储存与运输

-20°C储存,避免反复冻融。超低温运输 。请查阅批次 COA 获取详细规格。

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质量文档

SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。

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文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。

规格

产品名称
Recombinant Canis lupus CD19 Protein
别名
重组狗CD19蛋白 | 重组狗CD19分子蛋白
英文别名
B4 | B-lymphocyte antigen CD19 | B-lymphocyte surface antigen B4 | CD19 antigen | CD19 molecule | CD19 | CVID3 | Differentiation antigen CD19 | Leu-12 | MGC12802 | T-cell surface antigen Leu-12
规格或纯度
无动物源,无载体,His标签,Fc标签,PBS Only,≥90%(SDS-PAGE),见COA
生化机理
CD19 protein is a ransmembrane glycoprotein that plays a central role in B cell activation and humoral immune responses. CD19 is expressed throughout B cell development from pre-B cells through mature B cells, and it is commonly used as a B cell lineage marker. It is required for the responsiveness of mature B cell to antigen stimulation, germinal center development, and antibody affinity maturation. The CD19 protein associates with the B cell antigen receptor (BCR), CD81, CD38, CD21, CD22, and IFITM1/CD225/Leu13. These associations enable CD19 to amplify B cell signaling and reduce the threshold for antigen stimulation through the BCR. CD19 polymorphisms and up-regulation can lead to the development of autoimmunity by promoting autoantibody production. CD19 has emerged as promising therapeutic target for hematologic cancers and solid tumors. Immunotherapy using a chimeric antigen receptor (CAR) targeting CD19 has proven effective in many different cancers. The first CD19 CAR T cell therapies have been granted FDA approval for the treatment of B cell malignancies with several more in clinical trials. Mature human CD19 protein consists of a 272 amino acid (aa) extracellular domain (ECD) with two Ig-like domains, a 22 aa transmembrane segment, and a 243 aa cytoplasmic domain. Within the ECD, human CD19 shares 57% amino acid sequence identity with mouse and rat CD19.
表达系统
CHO
种属
狗(Canine)
氨基酸
74-350 aa
序列
MPPPRLLFFLLFLTPMEVRPQETLQVEAKEGGKAELPCLKVPSDGPLEQQAWFQGAQSELGLWSQGLGVRKGSLGIQLFVFNVSDQMGGFYLCQPGPPSEQAWQSGWTVSVEGSGELFRWNASALNDSGCGLGNRPSEGPKPSSRYPTSSQLYVWEKDHPEIWETDPECALPRGTLNQSLNQDLIVAPGSTFWLPCEVPPAFVARGPISWTHVRPKKHNISLLSLDLREDAPGREMWVLGTLSGGAVLLLPQATVRDAGTYRCYHGNRTVEMQLKVIAQSVRYWLLETGGWKVPAVPENLYFQGPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH
蛋白标签
C-hFc & His
无载体
Yes
无动物源
Yes
来源
重组表达
预测分子量
58.0 kDa
SDS-PAGE
68.4-95.7 kDa, under reducing conditions
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from PBS, pH 7.4
浓度
见COA
复溶
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
Store at -20℃ for 12 months. Upon reconstitution, it is recommended to aliquot. Avoid freeze/thaw cycle.
图片

combinant Canis lupus CD19 Protein (rp176268) - SDS-PAGE
3 μg/lane of Recombinant Canis lupus CD19 Protein was resolved with SDS-PAGE under reducing (R) and visualized by Coomassie® Blue staining, showing a band at 68.4-95.7 kDa.

技术文档

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找到3个结果

批号(Lot Number) 证书类型 货号
ZJ25F0927632 分析证书 rp176268
ZJ25F0927633 分析证书 rp176268
ZJ25F0927634 分析证书 rp176268
技术文档和文章
溶液计算器