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Recombinant Human Glypican 3 Protein (rp176299) - Binding Activity
Immobilized Recombinant Human FGF basic Protein (rp156010) at 1.0 μg/mL can bind Recombinant Human Glypican 3 Protein (rp176299) with the EC50 of 7.4 ng/mL.
ActiBioPure™,His标签,PBS Only,无动物源,无载体,生物活性 级 提供 ≥90%(SDS-PAGE) 纯度,适用于对基线干扰要求严格的色谱和分析工作流程。
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在色谱分析、有机合成和交叉偶联反应领域已被 1 篇同行评审文献引用。
Protein Function:
Glypican-3, also known as Intestinal protein OCI-5, GPC3, and OCI5, is a member of the glypican family. It belongs to the glypican family and is highly expressed in the lung, liver, and kidney. It is a heparan sulfate proteoglycan, which is overexpressed in various neoplasms such as hepatocellular carcinoma, malignant melanoma, and testicular yolk sac tumor, and plays an important role in cell growth and differentiation. GPC3 function is tissue-dependent. In some tissues, GPC3 acts as a tumor suppressor gene, whereas in others, it acts as an oncofetal protein. Studies have shown that GPC3 is a reliable marker for hepatocellular carcinoma. The sensitivity and specificity exceed both alpha-fetoprotein and hepatocyte-paraffin1. GPC3 immunohistochemistry can aid in the differentiation of testicular germ cell tumors, being expressed in all yolk sac tumors but not in seminomas. GPC3 expression has also been identified in some squamous cell carcinomas of the lung and clear cell carcinomas of the ovary. The role of GPC3 in melanomas is still controversial. Thus, Glypican-3 is currently regarded as a tumor marker and potential target for immunotherapy.
Recombinant Human Glypican 3 Protein (rp176299) - Binding Activity
Immobilized Recombinant Human FGF basic Protein (rp156010) at 1.0 μg/mL can bind Recombinant Human Glypican 3 Protein (rp176299) with the EC50 of 7.4 ng/mL.
Recombinant Human Glypican 3 Protein (rp176299) - Binding Activity
Immobilized Recombinant Human Glypican 3 Protein (rp176299) at 4.0 μg/mL can bind Recombinant Human FGF basic Protein (rp156010) with the EC50 of 441.4 ng/mL.
Recombinant Human Glypican 3 Protein (rp176299) - SDS-PAGE
2 μg/lane of Recombinant Human Glypican 3 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 30.0 kDa & 44.2 kDa & 66.2 kDa under reducing conditions and 60.0 kDa under non-reducing conditions.
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
| 分析证书 | rp176299 | |
| 分析证书 | rp176299 | |
| 分析证书 | rp176299 | |
| 分析证书 | rp176299 |
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