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Recombinant Human Glypican 3 Protein

货号: rp176299
COA
有货
级别和纯度: 无动物源 ? 无动物源（Animal Free）—— 不含动物源成分生产，降低污染风险。适用于避免动物源材料的生物制造和培养。 无载体 ? 无载体（Carrier Free）—— 不含添加的载体蛋白/稳定剂。当载体（如 BSA）会干扰偶联或敏感检测时使用。 生物活性 ? 生物活性级（Bioactive）—— 经验证在功能检测中保持生物活性。当分子须具有功能活性而不仅是纯度时使用。 ActiBioPure™ ? ActiBioPure™ —— 阿拉丁面向生物活性和重组产品的优质系列。当同时需要高纯度和保持生物活性时使用。 His标签 ? 组氨酸(His) 标签级 —— 带有 His 标签的重组蛋白，供亲和纯化/检测。用于纯化、固定或检测带标签蛋白。 PBS Only ? 仅 PBS 配方 —— 以磷酸盐缓冲液供应，不含其他添加剂。当需要不含稳定剂/载体的洁净 PBS 缓冲液时使用。 ≥90%(SDS-PAGE)
Accession #
P51654-1
蛋白标签
C-His
表达系统
HEK293
内毒素水平
<1.0 EU/μg
生物活性
Immobilized Recombinant Human Glypican 3 Protein (rp176299) at 4.0 μg/mL can bind Recombinant Human FGF basic Protein (rp156010) with the EC50 of 441.4 ng/mL. Immobilized Recombinant Human FGF basic Protein (rp156010) at 1.0 μg/mL can bind Recombinant Human Glypican 3 Protein (rp176299) with the EC50 of 7.4 ng/mL.
★
规格
库存
价格
数量
10μg
rp176299-10μg
现货 Stock Image
¥699.90
50μg
rp176299-50μg
现货 Stock Image
¥1,899.90
100μg
rp176299-100μg
现货 Stock Image
¥3,099.90
1mg
rp176299-1mg
期货 Stock Image
¥11,999.90
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大包装 / 定制
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SDS
安全数据
COA
分析证书
Data Sheet
产品数据
Spec Sheet
规格说明
大包装询价 收藏夹
Recombinant Human Glypican 3 Protein
概述 规格 储存与运输 图片 高级数据 质检证书(CoA,COO,BSE/TSE 和分析图谱) 技术文档和文章 溶液计算器

概述


Protein Function:
Glypican-3, also known as Intestinal protein OCI-5, GPC3, and OCI5, is a member of the glypican family. It belongs to the glypican family and is highly expressed in the lung, liver, and kidney. It is a heparan sulfate proteoglycan, which is overexpressed in various neoplasms such as hepatocellular carcinoma, malignant melanoma, and testicular yolk sac tumor, and plays an important role in cell growth and differentiation. GPC3 function is tissue-dependent. In some tissues, GPC3 acts as a tumor suppressor gene, whereas in others, it acts as an oncofetal protein. Studies have shown that GPC3 is a reliable marker for hepatocellular carcinoma. The sensitivity and specificity exceed both alpha-fetoprotein and hepatocyte-paraffin1. GPC3 immunohistochemistry can aid in the differentiation of testicular germ cell tumors, being expressed in all yolk sac tumors but not in seminomas. GPC3 expression has also been identified in some squamous cell carcinomas of the lung and clear cell carcinomas of the ovary. The role of GPC3 in melanomas is still controversial. Thus, Glypican-3 is currently regarded as a tumor marker and potential target for immunotherapy.

规格

产品名称
Recombinant Human Glypican 3 Protein
别名
重组人Glypican 3蛋白 | 重组人类磷脂酰肌醇蛋白聚糖 3 蛋白
英文别名
DGSX | Glypican 3 | glypican proteoglycan 3 | glypican-3 | GPC3 | heparan sulphate proteoglycan | Intestinal protein OCI-5 | MXR7 | OCI5 | OCI-5 | secreted glypican-3 | SGB | SGBS | SGBS1SDYS
规格或纯度
无动物源,无载体,生物活性,ActiBioPure™,His标签,PBS Only,≥90%(SDS-PAGE)
生物活性
Immobilized Recombinant Human Glypican 3 Protein (rp176299) at 4.0 μg/mL can bind Recombinant Human FGF basic Protein (rp156010) with the EC50 of 441.4 ng/mL. Immobilized Recombinant Human FGF basic Protein (rp156010) at 1.0 μg/mL can bind Recombinant Human Glypican 3 Protein (rp176299) with the EC50 of 7.4 ng/mL.
表达系统
HEK293
种属
人(Human)
氨基酸
1-559 aa
序列
MAGTVRTACLVVAMLLSLDFPGQAQPPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQVCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQEAFEIVVRHAKNYTNAMFKNNYPSLTPQAFEFVGEFFTDVSLYILGSDINVDDMVNELFDSLFPVIYTQLMNPGLPDSALDINECLRGARRDLKVFGNFPKLIMTQVSKSLQVTRIFLQALNLGIEVINTTDHLKFSKDCGRMLTRMWYCSYCQGLMMVKPCGGYCNVVMQGCMAGVVEIDKYWREYILSLEELVNGMYRIYDMENVLLGLFSTIHDSIQYVQKNAGKLTTTIGKLCAHSQQRQYRSAYYPEDLFIDKKVLKVAHVEHEETLSSRRRELIQKLKSFISFYSALPGYICSHSPVAENDTLCWNGQELVERYSQKAARNGMKNQFNLHELKMKGPEPVVSQIIDKLKHINQLLRTMSMPKGRVLDKNLDEEGFESGDCGDDEDECIGGSGDGMIKVKNQLRFLAELAYDLDVDDAPGNSQQATPKDNEISTFHNLGNVHHHHHH
蛋白标签
C-His
无载体
Yes
无动物源
Yes
来源
重组表达
预测分子量
61.5 kDa
SDS-PAGE
30.0 kDa & 44.2 kDa & 66.2 kDa, under reducing conditions; 60.0 kDa, under non-reducing conditions
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from PBS, pH 7.4
复溶
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 0.5 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
在 -20°C 下可保存 1 年。避免冷冻/解冻循环。
图片

Recombinant Human Glypican 3 Protein (rp176299) - Binding Activity
Immobilized Recombinant Human FGF basic Protein (rp156010) at 1.0 μg/mL can bind Recombinant Human Glypican 3 Protein (rp176299) with the EC50 of 7.4 ng/mL.

Recombinant Human Glypican 3 Protein (rp176299) - Binding Activity
Immobilized Recombinant Human Glypican 3 Protein (rp176299) at 4.0 μg/mL can bind Recombinant Human FGF basic Protein (rp156010) with the EC50 of 441.4 ng/mL.

Recombinant Human Glypican 3 Protein (rp176299) - SDS-PAGE
2 μg/lane of Recombinant Human Glypican 3 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 30.0 kDa & 44.2 kDa & 66.2 kDa under reducing conditions and 60.0 kDa under non-reducing conditions.

高级数据

质检证书(CoA,COO,BSE/TSE 和分析图谱)
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找到4个结果

批号(Lot Number) 证书类型 货号
ZJ26F0636438ZJ26F0636438 分析证书 rp176299
ZJ24F0707679ZJ24F0707679 分析证书 rp176299
ZJ24F0707680ZJ24F0707680 分析证书 rp176299
ZJ24F0707681ZJ24F0707681 分析证书 rp176299
技术文档和文章
阿拉丁®靶点蛋白
目录： 技术文章
探索主题:
药物开发 信号通路 细胞因子 靶点蛋白 药物靶点 受体 免疫检查点 细胞表面标记物
Aladdin® Target Proteins
目录： 技术文章
探索主题:
Cytokines Drug development Target Proteins Drug Targets Receptors Immune Checkpoints Cell Surface Markers Signaling Pathways
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