BLAST-2 | CD23 | CD23A | CD23CD23 antigen | CLEC4J | CLEC4JC-type lectin domain family 4 member J | C-type lectin domain family 4, member J | Fc epsilon RII | Fc fragment of IgE, low affinity II, receptor for (CD23) | FCE2Fc fragment of IgE, low affinity
Fc fragment of IgE, low affinity II, receptor for (CD23) or CD23 antigen is a member of the cluster of differentiation family. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Physiologically, CD molecules can act in numerous ways, often acting as receptors or ligands (the molecule that activates a receptor) important to the cell. A signal cascade is usually initiated, altering the behavior of the cell (see cell signaling). Some CD proteins do not play a role in cell signaling, but have other functions, such as cell adhesion. CD23/FCER2 is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Increased levels of soluble CD23/FCER2 cause the recruitment of non-sensitised B-cells in the presentation of antigen peptides to allergen-specific B-cells, therefore increasing the production of allergen specific IgE. IgE, in turn, is known to upregulate the cellular expression of CD23 and Fc epsilon RI (high-affinity IgE receptor).
Post-translational: N- and O-glycosylated. The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding.
生物活性
Immobilized Recombinant Human CD23/Fc epsilon RII Protein (rp176722) at 1.0 μg/mL can bind CD23 Antibody (Ab006720) with the EC50 of 106.2 ng/mL.
38.3 kDa, under reducing conditions; 36.3 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from PBS, pH 7.4.
浓度
见COA
复溶
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 0.5 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
Store at -20°C for 1 year. Avoid freeze/thaw cycle.
图片
Recombinant Human CD23/Fc epsilon RII Protein (rp176722) - ELISA Immobilized Recombinant Human CD23/Fc epsilon RII Protein (rp176722) at 1.0 μg/mL can bind CD23 Antibody (Ab006720) with the EC₅₀ of 106.2 ng/mL.
Recombinant Human CD23/Fc epsilon RII Protein (rp176722) - SDS-PAGE 3 μg/lane of Recombinant Human CD23/Fc epsilon RII Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 38.3 kDa under reducing conditions and 36.8 kDa under non-reducing conditions.