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340,000+ 科研产品 · 三重ISO认证 · 每个产品均提供COA和SDS · 现货产品当日发货

Recombinant Human Galectin-1 Protein

货号: rp179838
COA
有货
级别和纯度: 无载体 ? 无载体（Carrier Free）—— 不含添加的载体蛋白/稳定剂。当载体（如 BSA）会干扰偶联或敏感检测时使用。 生物活性 ? 生物活性级（Bioactive）—— 经验证在功能检测中保持生物活性。当分子须具有功能活性而不仅是纯度时使用。 ActiBioPure™ ? ActiBioPure™ —— 阿拉丁面向生物活性和重组产品的优质系列。当同时需要高纯度和保持生物活性时使用。 高性能 ? 高性能级 —— 纯度和性能特性经过优化。适用于普通等级无法满足的灵敏分析。 ≥95%(SDS-PAGE) 见COA
Accession #
P09382
蛋白标签
No tag
表达系统
E. coli
内毒素水平
<1.0 EU/μg
生物活性
Determined by its ability to chemoattract human monocytes using a concentration range of 10.0-100.0 ng/mL.
★
规格
库存
价格
数量
10μg
rp179838-10μg
现货 Stock Image
¥289.90
50μg
rp179838-50μg
现货 Stock Image
¥1,179.90
100μg
rp179838-100μg
现货 Stock Image
¥1,879.90
1mg
rp179838-1mg
现货 Stock Image
¥8,549.90
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SDS
安全数据
COA
分析证书
Data Sheet
产品数据
Spec Sheet
规格说明
大包装询价 收藏夹
Recombinant Human Galectin-1 Protein
规格 储存与运输 高级数据 质检证书(CoA,COO,BSE/TSE 和分析图谱) 溶液计算器

规格

产品名称
Recombinant Human Galectin-1 Protein
别名
重组人Galectin-1蛋白 | 重组人半乳糖凝集素-1蛋白
英文别名
14 kDa laminin-binding protein | 14 kDa lectin | Beta-galactoside-binding lectin L-14-I | BHL | GAL1 | gal-1 | Galaptin | galectin 1 | Galectin1 | Galectin-1 | GBP | HBL | HLBP14 | HPL | L-14 | Lactose-binding lectin 1 | Lectin galactoside-binding soluble 1 | lectin | LGALS1 | Putative MAPK-activating protein PM12 | S-Lac lectin 1 | galac 展开
规格或纯度
无载体, 生物活性, ActiBioPure™, 高性能, ≥95%(SDS-PAGE), 见COA
生化机理
Galectin-1, gene name LGALS1 (lectin, galactoside-binding, soluble 1), is a 135 amino acid (aa), 14 kDa, pleiotropic, non-glycosylated, monomeric or homodimeric carbohydrate-binding protein of the prototype galectin family. Galectins lack a classical signal peptide and can be localized to the cytosolic compartments, or secreted via non-classical pathways. Secreted Galectin-1 has immunosuppressive and anti-inflammatory properties and suppresses acute and chronic inflammation and autoimmunity. It contributes to negative selection of developing T cells, immunosuppression by regulatory T cells, resolution of the inflammatory response, and inhibition of immune cell migration, inflammatory cytokine production, and mast cell degranulation. Galectin-1 preferentially binds laminin, fibronectin, 90K/Mac-2BP, CD45, CD43, CD7, CD2, CD3, integrins alpha 4 beta 1, alpha 5 beta 1 and alpha 4 beta 7, and ganglioside GM1. It is produced in a variety of tissues by cells that include endothelial cells, connective tissue fibroblasts, thymic stromal cells, tumor cells, muscle cells, platelets, regulatory T cells, and activated tissue macrophages, B cells, T cells, and dendritic cells. Most of this expression is cytosolic. Human Galectin-1 shares 88% aa sequence identity with mouse, equine and ovine, 90% with rat, and 87% with bovine and porcine Galectin-1. Endothelial cell surface expression, including tumor endothelial cells, is greatly increased by cell activation. Galectin-1 is highly expressed at the maternal-fetal interface and contributes to fetal immune privilege. Its immunosuppressive properties appear to also allow tumor cells to evade immune detection. It selectively controls T cell survival by inducing apoptosis of activated Th1 and Th17 cells, which express Galectin-1-binding glycans, while promoting Th2 cell survival where glycans are sialylated and less recognized. It also induces apoptosis of immature thymocytes. Galectin-1 secreted from bone marrow stromal cells aids B lymphocyte development by contributing to pre-B cell integrin adhesion and receptor signaling. The dimer form of Galectin-1 also induces neutrophil down‑regulation by inducing cell surface exposure of phosphatidylserine that marks the cell for phagocytosis. Galectin-1 can also modulate cell-cell and cell-matrix interactions, and can promote either cell attachment or detachment depending on the cell type and developmental stage.
生物活性
Determined by its ability to chemoattract human monocytes using a concentration range of 10.0-100.0 ng/mL.
表达系统
E. coli
种属
人(Human)
氨基酸
2-135 aa
序列
ACGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD
蛋白标签
No tag
无载体
Yes
无动物源
No
来源
重组表达
预测分子量
14.6 kDa
SDS-PAGE
12.2 kDa, under reducing conditions
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
液体
储存缓冲液
PBS, 10% Glycerol, pH 7.4.
浓度
见COA
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
Store at -20°C for 1 year. Avoid freeze/thaw cycle.

高级数据

质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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找到4个结果

批号(Lot Number) 证书类型 货号
ZJ24F1215846ZJ24F1215846 分析证书 rp179838
ZJ24F1215847ZJ24F1215847 分析证书 rp179838
ZJ24F1215848ZJ24F1215848 分析证书 rp179838
ZJ24F1215849ZJ24F1215849 分析证书 rp179838
溶液计算器
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