Immobilized Recombinant Human Aldo-keto Reductase 1C3/AKR1C3 Protein (rp179839) at 1.0 μg/mL can bind Recombinant AKR1C3 Antibody (Ab087886) with the EC50 of 10.5 ng/mL.
17-beta-hydroxysteroid dehydrogenase type 5 | 3-alpha-HSD type 2 | 3-alpha-hydroxysteroid dehydrogenase type 2 | AKR1C3 | Aldo-keto Reductase 1C3 | aldo-keto reductase family 1 member C3 | aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid de
规格或纯度
无载体,生物活性,ActiBioPure™,His标签,≥95%(SDS-PAGE),见COA
生化机理
AKR1C3 is a member of the aldo-keto reductase (AKR) superfamily. It catalyzes oxidation/reduction reactions at the 3-alpha, 20-alpha, and 17-beta positions of steroids. It is also known as Prostaglandin F synthase as it reduces prostaglandin D2 to F2, and therefore may play a role in allergic conditions such as asthma. Elevated expression of AKR1C3 in endometrium that results in enhanced estrogen action may lead to endometrial cancer. It is also up‑regulated in squamous cell carcinoma of head and neck. AKR1C3 is found to be a novel suppressor of cell differentiation that provides a plausible target for the non-cyclooxygenase-dependent antineoplastic actions of nonsteroidal anti-inflammatory drugs.
生物活性
Immobilized Recombinant Human Aldo-keto Reductase 1C3/AKR1C3 Protein (rp179839) at 1.0 μg/mL can bind Recombinant AKR1C3 Antibody (Ab087886) with the EC50 of 10.5 ng/mL.
Store at -20°C for 1 year. Avoid freeze/thaw cycle.
图片
Recombinant Human Aldo-keto Reductase 1C3/AKR1C3 Protein (rp179839) - ELISA Immobilized Recombinant Human Aldo-keto Reductase 1C3/AKR1C3 Protein (rp179839) at 1.0 μg/mL can bind Recombinant AKR1C3 Antibody (Ab087886) with the EC₅₀ of 10.5 ng/mL.
Recombinant Human Aldo-keto Reductase 1C3/AKR1C3 Protein (rp179839) - SDS-PAGE 3 μg/lane of Recombinant Human Aldo-keto Reductase 1C3/AKR1C3 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 36.4 kDa under reducing conditions and 36.7 kDa under non-reducing conditions.