ActiBioPure™,His标签,无载体,生物活性 级 提供 ≥90%(SDS-PAGE) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
Protein Function:：
HTRA1 is a member of the mammalian HTRA (high temperature requirement A) serine protease family. The E. coli HTRA homolog functions as a chaperone-protease and is essential for bacterial survival at temperatures above 42 °C. Among the four mammalian HTRA proteins, HTRA1, -3 and -4 are secreted while HTRA2 is localized in mitochondria. HTRA1 contains an N-terminal insulin-like growth factor binding protein (IGFBP) domain, a Kazal-type trypsin inhibitor motif, and C-terminal trypsin-like protease and PDZ domains. It is involved in several pathologies including Alzheimer’s disease, rheumatoid arthritis, osteoarthritis and age‑related macular degeneration, although the mechanisms by which HTRA1 exerts its effects are not clear. HTRA1 also has properties of a tumor suppressor protein, which makes it a target for cancer therapy. In addition HTRA1 is known to regulate the TGF-beta signaling pathway and bone mineralization. Recombinant human HTRA1 lacks the N-terminal IGFBP and Kazal-like domains, but retains the serine protease and PDZ domains.
Recombinant Human HTRA1 Protein (rp179843) - Western Blot
0.5 mg/mL Casein(C110500) was incubated in 50mM Tris, pH 8.0, or with Recombinant Human HTRA1 Protein (rp179843). After various time intervals aliquots of the reaction mixtures were withdrawn and analyzed by SDS-PAGE.
Recombinant Human HTRA1 Protein (rp179843) - SDS-PAGE
3 μg/lane of Recombinant Human HTRA1 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 35.6 kDa under reducing conditions and 35.6 kDa under non-reducing conditions.
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 ZJ24F0809492 |
分析证书 | rp179843 |
| ZJ24F0809493 |
分析证书 | rp179843 |
| ZJ24F0809494 |
分析证书 | rp179843 |
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