His标签,PBS Only,无动物源,无载体 级 提供 ≥95%(SDS-PAGE) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
-20°C储存,避免反复冻融。超低温运输 。请查阅批次 COA 获取详细规格。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
Purity: ≥95%, by SDS-PAGE visualized with Coomassie® Blue Staining.
Description：
The MMR (macrophage mannose receptor) is also called MR due to its presence on cells other than macrophages, and is designated CD206, Mrc1 (mannose receptor C type 1), or CLEC13D (C‑type lectin domain family 13, member D). CD206 is a 175‑190 kDa endocytic receptor that is expressed on M2 alternatively activated tissue macrophages including tumor‑associated macrophages (TAMs), inflammatory dendritic cells in selected lymphoid organs, and liver, splenic, lymphatic, and dermal microvascular endothelial cells. The 1456 amino acid (aa) human CD206 precursor contains a signal sequence (18 aa), an extracellular domain (ECD) containing an N‑terminal cysteine‑rich domain, a fibronectin type II repeat, eight C‑type lectin domains (CTLDs), and several N‑glycosylation sites (1371 aa), a transmembrane segment and a short (46 aa) cytoplasmic domain. Metalloproteinases can mediate the shedding of the soluble ECD. The human CD206 ECD shares 83%, 84%, 89%, 89% and 90% aa sequence identity with mouse, rat, equine, porcine and canine CD206, respectively. The cysteine‑rich domain recognizes some pituitary hormones such as LH (luteinizing hormone/lutropin) and TSH (thyroid stimulating hormone/thyrotropin), chondroitin sulfates, and sulfated N‑acetylgalactosamines including sulfo‑Lewisa and ‑Lewisx. The FNII domain mediates Ca2+‑independent binding of collagens. The CTLDs participate in Ca2+‑dependent recognition of branched sugars with terminal mannose, fucose or N‑acetylglucosamine that occur on many pathogenic microorganisms. CD206 internalizes ligands in clathrin‑coated vesicles, sorts them to phagosomes or early endosomes, and recycles to the cell surface. CD206 also promotes clearance of glycoproteins that promote allergy or ongoing inflammation, such as lysosomal hydrolases and myeloperoxidases. It is involved in T cell polarization and production of pro‑ and anti‑inflammatory cytokines. It facilitates peptide presentation on MHC II, and cross‑presentation on MHC I which is important for tumor immunogenicity. This function may be blocked by engagement of CD206 on TAMs by tumor mucins.
Recombinant Human MMR/CD206 Protein (rp181274) - SDS-PAGE
3 μg/lane of Recombinant Human MMR/CD206 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 160.5-188.1 kDa under reducing conditions and 149.0-178.8 kDa under non-reducing conditions.
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 ZJ24F0606795 |
分析证书 | rp181274 |
| ZJ24F0606796 |
分析证书 | rp181274 |
| ZJ24F0606797 |
分析证书 | rp181274 |
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