CD46, also known as Membrane Cofactor Protein (MCP), is a complement regulatory protein. CD46 is a type 1 membrane protein that plays an important inhibitory role in the complement system. CD46 is expressed in white blood cells, platelets, epithelial cells, and fibroblasts. Human CD46 shares 5% amino acid sequence identity with mouse and rat CD46. The importance of CD46 to complement regulation is underscored by the observation that genetic loss of CD46 leads to development of atypical hemolytic-uremic syndrome (aHUS), a disease characterized by uncontrolled complement activation. CD46 is implicated in the development and/or progression of selected cancer types.
规格
产品名称
Recombinant Human CD46 Protein
别名
重组人CD46蛋白 | 重组人 CD46 蛋白
英文别名
CD46 antigen | CD46 molecule, complement regulatory protein | CD46 | MCP | membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen) | MIC10 | TLXcomplement regulatory protein | trophoblast leucocyte common antigen | AHUS2 | Trophobl
37.0-65.0 kDa, under reducing conditions; 42.0-63.0 kDa, under non-reducing conditions
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from PBS, pH 7.4
复溶
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
在 -20°C 下可保存 1 年。避免冷冻/解冻循环。
图片
Recombinant Human CD46 Protein (rp181587) - SDS-PAGE 3 μg/lane of Recombinant Human CD46 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 37.0-65.0 kDa under reducing conditions and 42.0-63.0 kDa under non-reducing conditions.
Recombinant Human CD46 Protein (rp181587) - ELISA Immobilized Recombinant Human CD46 Protein (rp181587) at 1.0 μg/mL can bind Recombinant CD46 Antibody (Ab094952) with the EC50 of 5.7 ng/mL.
ZJ25F0825377
危险品化学品经营许可证（带存储）