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Recombinant Human Lumican Protein

货号: rp181608
COA
有货
级别和纯度: 无动物源 ? 无动物源（Animal Free）—— 不含动物源成分生产，降低污染风险。适用于避免动物源材料的生物制造和培养。 无载体 ? 无载体（Carrier Free）—— 不含添加的载体蛋白/稳定剂。当载体（如 BSA）会干扰偶联或敏感检测时使用。 生物活性 ? 生物活性级（Bioactive）—— 经验证在功能检测中保持生物活性。当分子须具有功能活性而不仅是纯度时使用。 ActiBioPure™ ? ActiBioPure™ —— 阿拉丁面向生物活性和重组产品的优质系列。当同时需要高纯度和保持生物活性时使用。 高性能 ? 高性能级 —— 纯度和性能特性经过优化。适用于普通等级无法满足的灵敏分析。 His标签 ? 组氨酸(His) 标签级 —— 带有 His 标签的重组蛋白，供亲和纯化/检测。用于纯化、固定或检测带标签蛋白。 PBS Only ? 仅 PBS 配方 —— 以磷酸盐缓冲液供应，不含其他添加剂。当需要不含稳定剂/载体的洁净 PBS 缓冲液时使用。 ≥95%(SDS-PAGE)
Accession #
P51884
蛋白标签
C-His
表达系统
HEK293
内毒素水平
<1.0 EU/μg
生物活性
Measured by the ability of the immobilized protein to support the adhesion of A375 human melanoma cells. The ED50 for this effect is 1.01 μg/mL.
★
规格
库存
价格
数量
10μg
rp181608-10μg
现货 Stock Image
¥599.90
50μg
rp181608-50μg
现货 Stock Image
¥1,699.90
100μg
rp181608-100μg
现货 Stock Image
¥2,599.90
1mg
rp181608-1mg
现货 Stock Image
¥15,999.90
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SDS
安全数据
COA
分析证书
Data Sheet
产品数据
Spec Sheet
规格说明
大包装询价 收藏夹
Recombinant Human Lumican Protein
概述 规格 储存与运输 图片 高级数据 质检证书(CoA,COO,BSE/TSE 和分析图谱) 技术文档和文章 溶液计算器

概述


Lumican is a 40 kDa member of the family of small leucine-rich repeat proteoglycans (SLRPs) and the class II subfamily. Human Lumican is synthesized as a 338 amino acid (aa) precursor that contains an 18 aa signal sequence and a 320 aa mature chain. The mature chain contains a negatively charged N-terminal domain containing sulfated tyrosine and disulfide bonds, 12 leucine-rich repeats (LRRs), four potential sites of N-linked glycosylation, and a carboxyl terminal domain containing two conserved cysteines. Mature human Lumican is 88%, 87%, and 70% aa identical to mature mouse, rat, and chick Lumican, respectively. SLRPs constitute an important fraction of noncollagenous extracellular matrix proteins (ECM) proteins. Lumican is expressed in a variety of tissues, including skin, artery, lung, cornea, kidney, bone, aorta, and articular cartilage. Lumican’s role in vivo has been found using Lumican null mice. These mice have functional deficits including corneal opacity as well as skin and tendon fragility associated with disorganized and loosely packed collagen fibers. The abnormal connective tissue phenotype seen in the Lumican null mice shows the importance of the role of Lumican in collagen fibrillogenesis. In addition to the control of collagen fibril assembly, Lumican has been shown to play a role in the regulation of cell proliferation, migration, and adhesion. Lumican’s over-expression has been reported in carcinoid tumor, breast, colorectal, neuroendocrine, uterine cervical and pancreatic cancers.

规格

产品名称
Recombinant Human Lumican Protein
别名
重组人Lumican蛋白
英文别名
LDC | LUM | lumican proteoglycan | Lumican | SLRR2D | SLRR2DLDCKeratan sulfate proteoglycan lumican | Keratan sulfate proteoglycan lumican | KSPG lumican
规格或纯度
无动物源,无载体,生物活性,ActiBioPure™,高性能,His标签,PBS Only,≥95%(SDS-PAGE)
生物活性
Measured by the ability of the immobilized protein to support the adhesion of A375 human melanoma cells. The ED50 for this effect is 1.01 μg/mL.
表达系统
HEK293
种属
人(Human)
氨基酸
1-338 aa
序列
MSLSAFTLFLALIGGTSGQYYDYDFPLSIYGQSSPNCAPECNCPESYPSAMYCDELKLKSVPMVPPGIKYLYLRNNQIDHIDEKAFENVTDLQWLILDHNLLENSKIKGRVFSKLKQLKKLHINHNNLTESVGPLPKSLEDLQLTHNKITKLGSFEGLVNLTFIHLQHNRLKEDAVSAAFKGLKSLEYLDLSFNQIARLPSGLPVSLLTLYLDNNKISNIPDEYFKRFNALQYLRLSHNELADSGIPGNSFNVSSLVELDLSYNKLKNIPTVNENLENYYLEVNQLEKFDIKSFCKILGPLSYSKIKHLRLDGNRISETSLPPDMYECLRVANEVTLNHHHHHH
蛋白标签
C-His
无载体
Yes
无动物源
Yes
来源
重组表达
预测分子量
37.5 kDa
SDS-PAGE
44.2-54.7 kDa, under reducing conditions; 44.0-54.5 kDa, under non-reducing conditions
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from PBS, pH 7.4
复溶
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
在 -20°C 下可保存 1 年。避免冷冻/解冻循环。
图片

Recombinant Human Lumican Protein (rp181608) - Protein Bioactivity
Measured by the ability of the immobilized protein to support the adhesion of A375 human melanoma cells. The ED ₅₀ for this effect is 1.01 μg/mL.

Recombinant Human Lumican Protein (rp181608) - SDS-PAGE
3 μg/lane of Recombinant Human Lumican Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 44.2-54.7 kDa under reducing conditions and 44.0-54.5 kDa under non-reducing conditions.

高级数据

质检证书(CoA,COO,BSE/TSE 和分析图谱)
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找到4个结果

批号(Lot Number) 证书类型 货号
ZJ24F0707724ZJ24F0707724 分析证书 rp181608
ZJ24F0707725ZJ24F0707725 分析证书 rp181608
ZJ24F0707726ZJ24F0707726 分析证书 rp181608
ZJ24F0707727ZJ24F0707727 分析证书 rp181608
技术文档和文章
阿拉丁®靶点蛋白
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探索主题:
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