Immobilized Recombinant Human PBEF/Visfatin Protein (rp183590) at 1.0 μg/mL can bind Recombinant Visfatin Antibody (Ab134271) with the EC50 of 4.18 ng/mL.
催化烟酰胺与 5-磷酸核糖基-1-焦磷酸缩合,生成烟酰胺单核苷酸,这是生物合成 NAD 的中间体。它是哺乳动物 NAD 生物合成途径中的限速成分。分泌型既是一种具有免疫调节特性的细胞因子,也是一种具有抗糖尿病特性的脂肪因子,它没有酶活性,部分原因是缺乏 ATP 的激活,而 ATP 在细胞外空间和血浆中的含量很低。在调节昼夜节律钟功能方面发挥作用。NAMPT 依赖于 NAD 的振荡产生,通过释放核心时钟成分来调节时钟目标基因表达的振荡:CLOCK-BMAL1异二聚体不受 NAD 依赖性 SIRT1 介导的抑制(相似)。
生物活性
Immobilized Recombinant Human PBEF/Visfatin Protein (rp183590) at 1.0 μg/mL can bind Recombinant Visfatin Antibody (Ab134271) with the EC50 of 4.18 ng/mL.
Recombinant Human PBEF/Visfatin Protein (rp183590) - ELISA Immobilized Recombinant Human PBEF/Visfatin Protein (rp183590) at 1.0 μg/mL can bind Recombinant Visfatin Antibody (Ab134271) with the EC50 of 4.18 ng/mL.
Recombinant Human PBEF/Visfatin Protein (rp183590) - SDS-PAGE 3 μg/lane of Recombinant Human PBEF/Visfatin Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 54.6 kDa.