1. Immobilized Recombinant Human Axl Protein (rp183600) at 1.0 μg/mL can bind Tilvestamab (anti-AXL) (Ab182880) with the EC50 of 11.51 ng/mL. 2. Immobilized Recombinant Human Axl Protein (rp183600) at 1.0 μg/mL can bind Enapotamab (anti-AXL) (Ab177845) with the EC50 of 2.766 ng/mL.
Axl, also known as Ufo and Ark, is a widely expressed 140 kDa glycoprotein in the TAM receptor tyrosine kinase family. TAM family receptors (Dtk/Tyro3, Axl, and Mer) are involved in regulation of the inflammatory response, cell survival and migration, and tumorigenesis. Mature human Axl consists of a 426 aa extracellular domain (ECD) that contains two Ig-like domains and two fibronectin type III domains, a 21 aa transmembrane segment, and a 422 aa cytoplasmic domain that includes the tyrosine kinase domain. Within the ECD, human Axl shares approximately 82% aa sequence identity with mouse and rat Axl. A short alternately spliced form of human Axl has a 9 aa deletion in the extracellular juxtamembrane region. Axl binds the vitamin K-dependent protein Gas6 which triggers tyrosine autophosphorylation of the Axl cytoplasmic domain. Activation of Axl induces a broad range of activities including platelet aggregation and thrombus formation, macrophage and dendritic cell phagocytosis of apoptotic cells, NK cell development from hematopoietic progenitor cells, and in vivo angiogenesis. Axl is highly expressed in solid cancers and promotes in vivo tumorigenesis and tumor cell invasiveness. It contributes to vascular remodeling and inflammatory cell infiltration in response to hypertension and restricted blood flow. It also functions as a cellular entry receptor for Gas6-opsonized lentiviruses. A 70-80 kDa soluble portion of the Axl ECD can be shed by proteolytic cleavage, and this fragment retains the ability to bind Gas6.
规格
产品名称
Recombinant Human Axl Protein
别名
重组人Axl蛋白 | 重组人Axl蛋白
英文别名
AI323647 | Adhesion related kinase | Ark | Axl | AXL oncogene | AXL receptor tyrosine kinase | AXL transforming gene | AXL transforming sequence/gene | EC 2.7.10.1 | JTK11 | Oncogene AXL | Tyro7 | Tyrosine protein kinase receptor UFO | Tyrosine-protein ki
1. Immobilized Recombinant Human Axl Protein (rp183600) at 1.0 μg/mL can bind Tilvestamab (anti-AXL) (Ab182880) with the EC50 of 11.51 ng/mL. 2. Immobilized Recombinant Human Axl Protein (rp183600) at 1.0 μg/mL can bind Enapotamab (anti-AXL) (Ab177845) with the EC50 of 2.766 ng/mL.
53.9-77.0 kDa, under reducing conditions; 49.3-70.8 kDa, under non-reducing conditions
分子类型
蛋白质
产品线
biological_products
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from PBS, pH 7.4
复溶
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 0.5 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
在 -20°C 下可保存 1 年。避免冷冻/解冻循环。
图片
Recombinant Human Axl Protein (rp183600) - ELISA Immobilized Recombinant Human Axl Protein (rp183600) at 1.0 μg/mL can bind Tilvestamab (anti-AXL) (Ab182880) with the EC50 of 11.51 ng/mL.
Recombinant Human Axl Protein (rp183600) - ELISA Immobilized Recombinant Human Axl Protein (rp183600) at 1.0 μg/mL can bind Enapotamab (anti-AXL) (Ab177845) with the EC50 of 2.766 ng/mL.
Recombinant Human Axl Protein (rp183600) - SDS-PAGE 3 μg/lane of Recombinant Human Axl Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 53.9-77.0 kDa under reducing conditions and 49.3-70.8 kDa under non-reducing conditions.
Recombinant Human Axl Protein (rp183600) - ELISA Immobilized Recombinant Human AXL protein (rp183600) at 1.0 μg/mL can bind Mipasetamab (anti-AXL) (Ab183002) with the EC
₅₀
of 24.0 ng/mL.
ZJ24F0809585
危险品化学品经营许可证（带存储）