Immobilized Recombinant Human Ephrin-A5 Protein (rp183615) at 1.0 μg/mL can bind Recombinant Human EphA4 Protein (rp183616) with the EC50 of 175.1 ng/mL.
Ephrin-A5 also known as EFNA5, is a member of the Ephrin family. The Eph family receptor interacting proteins (ephrins) are a family of proteins that serve as the ligands of the Eph receptor, which compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs). Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. Ephrin-A5/EFNA5 may function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Ephrin-A5/EFNA5 also serves as a cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.
生物活性
Immobilized Recombinant Human Ephrin-A5 Protein (rp183615) at 1.0 μg/mL can bind Recombinant Human EphA4 Protein (rp183616) with the EC50 of 175.1 ng/mL.
26.0 kDa, under reducing conditions; 25.1 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from PBS, pH 7.4.
复溶
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 0.5 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
Store at -20°C for 1 year. Avoid freeze/thaw cycle.
图片
Recombinant Human Ephrin-A5 Protein (rp183615) - Binding Activity Immobilized Recombinant Human Ephrin-A5 Protein (rp183615) at 1.0 μg/mL can bind Recombinant Human EphA4 Protein (rp183616) with the EC50 of 175.1 ng/mL.
Recombinant Human Ephrin-A5 Protein (rp183615) - SDS-PAGE 3 μg/lane of Recombinant Human Ephrin-A5 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 26.0 kDa under reducing conditions and 25.1 kDa under non-reducing conditions.