EC 2.7.1.40 | PK1 | PK1PKRL | PKL | PKLR | PKR | Pyruvate Kinase 1 | pyruvate kinase isozyme R/L | pyruvate kinase isozymes R/L | pyruvate kinase type L | pyruvate kinase | Red cell/liver pyruvate kinase | RPK | R-type/L-type pyruvate kinase | liver and b
规格或纯度
无载体,His标签,≥95%(SDS-PAGE),见COA
生化机理
Pyruvate kinases (PK) are glycolytic enzymes that catalyze the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP, the final step in the glycolysis pathway. There are 4 isozymes of pyruvate kinase in mammals: L, R, M1, and M2. L type is the major isozyme in the liver, R is found in red cells, M1 is the main form in muscle, heart, and brain, and M2 is found in early fetal tissues. R and L types are encoded in the same gene and caused by different splicing. The 33 amino acids from the N-terminus in the R type are replaced with Met and Glu in the L type. PKLR is allosterically activated by fructose 1,6-bisphosphate. Mutation of PKLR is a frequent cause of hereditary non-spherocytic hemolytic anemia.
Store at -20°C for 1 year. Avoid freeze/thaw cycle.
图片
Recombinant Human PKLR Protein (rp183692) - SDS-PAGE 3 μg/lane of Recombinant Human PKLR Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 56.9 kDa.
ZJ25F0116455
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