Protein Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands. Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups (PubMed:14573603, PubMed:18042734, PubMed:19589875, PubMed:21187059, PubMed:2268288, PubMed:29671343, PubMed:7678732, PubMed:7854148). Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis (PubMed:14573603, PubMed:19589875, PubMed:21187059). Plays a key role in bile acid metabolism (PubMed:2268288). In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols (By similarity).
规格
产品名称
Recombinant Human SULT2A1/ST2 Protein
别名
重组人SULT2A1/ST2蛋白 | 重组人 SULT2A1/ST2 蛋白
英文别名
Bile salt sulfotransferase 2A1 | Alcohol/hydroxysteroid sulfotransferase | Bile salt sulfotransferase | Dehydroepiandrosterone sulfotransferase | DHEA ST | Sult2a1 | DHEA sulfotransferase | DHEA-ST | DHEAS | EC 2.8.2.14 | Hst | hSTa | Hydroxysteroid sulfo
32.6 kDa, under reducing conditions; 31.9 kDa, under non-reducing conditions
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
液体
储存缓冲液
50mM Tris, 500mM NaCl, 20% Glycerol, pH 8.0
浓度
见COA
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
在 -20°C 下可保存 1 年。避免冷冻/解冻循环。
图片
Recombinant Human SULT2A1/ST2 Protein (rp183708) - SDS-PAGE 3 μg/lane of Recombinant Human SULT2A1/ST2 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 32.6 kDa under reducing conditions and 31.9 kDa under non-reducing conditions.