Sulfotransferase family cytosolic 2B member 1, also known as Sulfotransferase 2B1, ST2B1, Alcohol sulfotransferase, Hydroxysteroid sulfotransferase 2, SULT2B1 and HSST2, is a cytoplasm protein that belongs to the sulfotransferase 1 family. The human hydroxysteroid sulfotransferase (SULT) family is comprised of two subfamilies, SULT2A1 and SULT2B1. SULT2B1 is expressed highly in placenta, prostate and trachea. A lesser expression of SULT1B1 was observed in the small intestine and lung. SULT2B1 catalyzes the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. SULT2B1 sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol. The two SULT2B1 isoforms, SULT2B1a and SULT2B1b, are encoded by a single gene as a result of alternative transcription initiation and alternative splicing. SULT2B1b catalyzes the sulfonation of 3beta-hydroxysteroid hormones and cholesterol, whereas SULT2B1a preferentially catalyzes pregnenolone sulfonation.
Post-translational: Phosphorylated.
生物活性
Immobilized Recombinant Human SULT2B1 Protein (rp183709) at 1.0 μg/mL can bind SULT2B1 Mouse mAb (Ab129738) with the EC50 of 86.8 ng/mL.
32.2 kDa, under reducing conditions; 32.2 & 62.7 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
液体
储存缓冲液
20mM Tris, 10% Glycerol, pH 7.5.
浓度
见COA
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
Store at -20°C for 1 year. Avoid freeze/thaw cycle.
图片
Recombinant Human SULT2B1 Protein (rp183709) - ELISA Immobilized Recombinant Human SULT2B1 Protein (rp183709) at 1.0 μg/mL can bind SULT2B1 Mouse mAb (Ab129738) with the EC₅₀ of 86.8 ng/mL.
Recombinant Human SULT2B1 Protein (rp183709) - SDS-PAGE 3 μg/lane of Recombinant Human SULT2B1 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 32.2 kDa under reducing conditions and 32.2 & 62.7 kDa under non-reducing conditions.
The cytosolic sulfotransferases (SULTs) are dimeric enzymes that help maintain homeostasis through the modulation of hormone and drug activity by catalyzing their transformation into hydrophilic sulfate esters and increasing their excretion (PMID: 25760527).
ZJ25F0319493
危险品化学品经营许可证（带存储）