Immobilized Recombinant Human Prealbumin Protein (rp183710) at 1.0 μg/mL can bind Recombinant Prealbumin Antibody (Ab008402) with the EC50 of 8.3 ng/mL.
Prealbumin is a thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain. Prealbumin is a carrier protein which transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. Transthyretin consists of a tetramer of identical subunits and is dominantly produced in the liver. Mutations in Prealbumin are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, and carpal tunnel syndrome. Prealbumin is an indicator of protein-energy malnutrition since it has a circulating half life of 2 days and reacts swiftly to changes in nutritional status.
Post-translational: Not glycosylated under normal conditions. Following unfolding, caused for example by variant AMYLD1 'Gly-38', the cryptic Asn-118 site is exposed and glycosylated by STT3B-containing OST complex, leading to its degradation by the ER-associated degradation (ERAD) pathway. Sulfonation of the reactive cysteine Cys-30 enhances the stability of the native conformation of TTR, avoiding misassembly of the protein leading to amyloid formation.
生物活性
Immobilized Recombinant Human Prealbumin Protein (rp183710) at 1.0 μg/mL can bind Recombinant Prealbumin Antibody (Ab008402) with the EC50 of 8.3 ng/mL.
15.4 & 32.2 kDa, under reducing conditions; 15.4 & 32.2 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from PBS, pH 7.4
浓度
见COA
复溶
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
短期储存2-8℃(1-2周);长期储存-20℃(12个月);收货后建议分装,避免反复冻融。
图片
Recombinant Human Prealbumin Protein (rp183710) - ELISA Immobilized Recombinant Human Prealbumin Protein (rp183710) at 1.0 μg/mL can bind Recombinant Prealbumin Antibody (Ab008402) with the EC50 of 8.3 ng/mL.
uman Prealbumin Protein (rp183710) - SDS-PAGE 3 μg/lane of Recombinant Human Prealbumin Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 15.4 & 32.2 kDa. Human Prealbumin Protein is also capable of forming multimers (PMID: 10052934).