AREB 6 | AREB6 | BZP | Delta crystallin enhancer binding factor 1 | DELTA EF1 | FECD6 | MGC133261 | Negative regulator of IL 2 | Negative regulator of IL2 | NIL 2 A | NIL 2 A zinc finger protein | NIL 2A | NIL-2-A zinc finger protein | NIL2A | Posterior p
规格或纯度
无载体,生物活性,ActiBioPure™,His标签,≥90%(SDS-PAGE),See COA
生化机理
Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity).
Post-translational: Ubiquitinated, leading to degradation in a proteasome-dependent manner. Deubiquitinated by USP51, leading to stabilization.
生物活性
Immobilized Recombinant Human ZEB1 Protein (rp184861) at 1.0 μg/mL can bind Recombinant ZEB1 Antibody (Ab135194) with the EC50 of 4.2 ng/mL.
Store at -20°C for 1 year. Avoid freeze/thaw cycle.
图片
Recombinant Human ZEB1 Protein (rp184861) - ELISA Immobilized Recombinant Human ZEB1 Protein (rp184861) at 1.0 μg/mL can bind Recombinant ZEB1 Antibody (Ab135194) with the EC₅₀ of 4.2 ng/mL.
Recombinant Human ZEB1 Protein (rp184861) - SDS-PAGE 2 μg/lane of Recombinant Human ZEB1 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 60.2 kDa under reducing conditions.