FGF12 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. FGF12 lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, FGF12 accumulated in the nucleus, but was not secreted. The specific function of FGF12 gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.
生物活性
Immobilized Recombinant Human FGFR4 Protein (rp146021) at 1.0 μg/mL can bind Recombinant Human FGF12 Protein (rp184901) with the EC50 of 179.7 ng/mL.
Store at -20°C for 1 year. Avoid freeze/thaw cycle.
图片
Recombinant Human FGF-12 Protein (rp184901) - Binding Activity Immobilized Recombinant Human FGFR4 Protein (rp146021) at 1.0 μg/mL can bind Recombinant Human FGF-12 Protein (rp184901) with the EC₅₀ of 179.7 ng/mL.
Recombinant Human FGF-12 Protein (rp184901) - SDS-PAGE 3μg/lane of Recombinant Human FGF-12 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 18.1 kDa under reducing conditions and 18.0 & 37.9 kDa under non-reducing conditions. Heparin/ HS can facilitate the oligomerization of two or more FGF molecules, which may be important for receptor dimerization and activation.(PubMed: 7536345)