Recombinant Human PDGF-CC Protein

Name: Recombinant Human PDGF-CC Protein
SKU: rp184963
Availability: InStock

货号: rp184963

COA

有货

级别和纯度: 无动物源 ? 无载体 ? 生物活性 ? ActiBioPure™ ? 高性能 ? His标签 ? Fc标签 ? ≥90%(SDS-PAGE) 见COA

Accession #

Q9NRA1

蛋白标签

N-His & hFc

表达系统

HEK293

内毒素水平

<1.0 EU/μg

生物活性

Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 374.3 ng/mL.

规格

库存

价格

数量

10μg

rp184963-10μg

期货

¥599.90

50μg

rp184963-50μg

期货

¥1,769.90

100μg

rp184963-100μg

期货

¥2,829.90

1mg

rp184963-1mg

期货

¥19,999.90

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规格储存与运输图片技术文档高级数据质检证书（CoA,COO,BSE/TSE 和分析图谱) 技术文档和文章溶液计算器

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为什么选择此级别

ActiBioPure™,Fc标签,His标签,无动物源,无载体,生物活性,高性能级提供 ≥90%(SDS-PAGE) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。

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储存与运输

-20°C储存,避免反复冻融。超低温运输。请查阅批次 COA 获取详细规格。

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质量文档

SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。

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文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。

规格

产品名称

Recombinant Human PDGF-CC Protein

别名

重组人PDGF-CC蛋白 | 重组人PDGF-CC蛋白 | 重组人血小板衍生生长因子CC蛋白

英文别名

规格或纯度

无动物源,无载体,生物活性,ActiBioPure™,高性能,His标签,Fc标签,≥90%(SDS-PAGE),见COA

生化机理

PDGF-C is a member of the PDGF/VEGF family of growth factors with a unique domain organization and expression pattern. Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine kinase activity. They have roles in the regulation of many biological processes including embryonic development, angiogenesis, cell proliferation and differentiation, and contribute to the pathophysiology of some diseases, including cancer. There are two isoforms of the PDGFR receptor; PDGFRalpha and PDGFRbeta, which can form homo- or heterodimers. The endogenous PDGFR ligands are PDGF-A, -B, -C and -D, which induce receptor dimerization and transphosphorylation at specific tyrosine residues upon binding. This activates the intracellular kinase activity, initiating intracellular signaling through the MAPK, PI 3-K and PKCgamma pathways. PDGF-C acts as a specific ligand for alpha platelet-derived growth factor receptor homodimer, and alpha and beta heterodimer. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. PDGF-C appears to be involved in the three stages of wound healing: inflammation, proliferation and remodeling. PDGF-C is involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. Post-translational: Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after basic residues in the hinge region (region connecting the CUB and growth factor domains) gives rise to the receptor-binding form. Cleaved by PLAT and PLG. Sumoylated with SUMO1. N-glycosylated.

生物活性

Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 374.3 ng/mL.

表达系统

HEK293

种属

人(Human)

氨基酸

235-345 aa

序列

HHHHHHPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKENLYFQGVVDLNLLTEEVRLYSCTPRNFSVSIREELKRTDTIFWPGCLLVKRCGGNCACCLHNCNECQCVPSKVTKKYHEVLQLRPKTGVRGLHKSLTDVALEHHEECDCVCRGSTGG

蛋白标签

N-His & hFc

无载体

Yes

无动物源

Yes

来源

重组表达

预测分子量

40.1 kDa

SDS-PAGE

44.8 & 100.0k kDa, under reducing conditions

分子类型

蛋白质

产品线

生物产品

储存与运输

物理形态

冻干(Lyophilized)

储存缓冲液

Lyophilized from PBS, pH 7.4.

浓度

见COA

复溶

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.

储存条件

-20°C储存,避免反复冻融

运输条件

超低温运输

稳定性与储存

-20℃保存 6个月；复溶后建议分装，避免反复冻融。

图片

Protein Bioactivity: Recombinant Human PDGF-CC Protein (rp184963)

Recombinant Human PDGF-CC Protein (rp184963) - Protein Bioactivity

Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. The ED₅₀ for this effect is 374.3 ng/mL.

SDS-PAGE: Recombinant Human PDGF-CC Protein (rp184963)

Recombinant Human PDGF-CC Protein (rp184963) - SDS-PAGE

3 μg/lane of Recombinant Human PDGF-CC Protein was resolved with SDS-PAGE under reducing (R) and visualized by Coomassie® Blue staining, showing the bands at 44.8 & 100.0 kDa.

技术文档

📋 安全数据表 (SDS)

全面的危险、操作、储存及法规合规文件。

下载 SDS →

✅ 分析证书 (COA)

批次质量数据。输入批号以获取对应 COA。

查询 COA →

📊 产品数据表

产品规格和应用的快速参考摘要。

查看数据表 →

🔬 规格说明书

该级别的完整质量属性和验收标准。

查看规格说明 →

高级数据

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

技术文档和文章

血小板衍生生长因子PDGF在细胞增殖、血管重塑与组织修复中的应用研究

目录：技术文章

探索主题:

纤维化组织修复周细胞 PDGF 血小板衍生生长因子 PDGFR PDGF-AA PDGF-BB 成纤维细胞平滑肌细胞

Application Research of Platelet-Derived Growth Factor (PDGF) in Cell Proliferation, Vascular Remodeling, and Tissue Repair

目录：技术文章

探索主题:

fibrosis Tissue repair pericytes PDGF PDGFR PDGF-AA PDGF-BB Platelet-derived growth factor Fibroblasts Smooth muscle cells

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摩尔浓度计算器

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质量

浓度

体积

分子量

g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

浓度1（C1）

体积 1 (V1)

浓度 2 (C2)

体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

质量（小瓶）

所需的复溶浓度

需要帮助选择级别？

我们的级别选择指南涵盖了目录中所有的变体的纯度、稳定剂状态和应用适用性。

查看 Animal Free 级别指南 → 查看 Carrier Free 级别指南 → 查看 Bioactive 级别指南 → 查看 ActiBioPure™ 级别指南 → 查看 High Performance 级别指南 → 查看 His Tag 级别指南 → 查看 Fc tag 级别指南 →

大包装与定制包装 需要更大包装或定制规格？请联系我们的团队获取专属报价。

Recombinant Human PDGF-CC Protein

储存与运输

质量文档

文献证明

规格

技术文档

📋 安全数据表 (SDS)

✅ 分析证书 (COA)

📊 产品数据表

🔬 规格说明书

高级数据

摩尔浓度计算器

稀释计算器

复溶计算器

需要帮助选择级别？

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