Recombinant Human Topoisomerase II alpha/TOP2A Protein
别名
重组人Topoisomerase II alpha/TOP2A蛋白 | 重组人DNA拓扑异构酶2-α蛋白 | 重组人Topoisomerase II alpha/TOP2A蛋白 | 重组人DNA拓扑异构酶IIα
英文别名
alpha isozyme | ATP hydrolyzing DNA topoisomerase II alfa | DNA gyrase | DNA topoisomerase (ATP hydrolyzing) | DNA topoisomerase 2 alpha | DNA topoisomerase 2-alpha | DNA topoisomerase II | DNA topoisomerase II 170 kD | DNA topoisomerase II alpha isozyme
规格或纯度
无载体,≥95%(SDS-PAGE),见COA
生化机理
DNA topoisomerase 2-alpha (TOP2A) is also known as DNA topoisomerase II, alpha isozyme and TOP2. It is a topoisomerase which control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation. Also it is the targets of anti-cancer drugs that cause treatment-related leukemias with balanced translocations.
Post-translational: Phosphorylation has no effect on catalytic activity. However, phosphorylation at Ser-1106 by CSNK1D/CK1 promotes DNA cleavable complex formation.(Microbial infection) Deubiquitinated by Epstein-Barr virus BPLF1; leading to stabilized SUMOylated TOP2A trapped in cleavage complexes, which halts the DNA damage response to TOP2A-induced double-strand DNA breaks.SUMOylated.
19.3 kDa, under reducing conditions; 19.3 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
液体
储存缓冲液
20mM Tris, 500mM NaCl, 5% Glycerol, pH 8.0
浓度
见COA
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
-20℃ 存储12个月；收货后建议分装，避免反复冻融。
图片
Recombinant Human Topoisomerase II alpha Protein (rp186556) - SDS-PAGE 3 μg/lane of Recombinant Human Topoisomerase II alpha Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 19.3 kDa.
ZJ25F0521118
危险品化学品经营许可证（带存储）