Carbonyl reductase 2 | Carbonyl reductase II | DCR | Dcxr | DCXR_HUMAN | Dicarbonyl and L xylulose reductase | Dicarbonyl L xylulose reductase | Dicarbonyl/ L xylulose reductase | Dicarbonyl/L-xylulose reductase | HCR2 | HCRII | Human carbonyl reductase 2
规格或纯度
无载体,His标签,≥95%(SDS-PAGE),See COA
生化机理
DCXR, also known as HCR2, belongs to the short-chain dehydrogenases/reductases (SDR) family. It is highly expressed in kidney, liver and epididymis. In the epididymis, DCXR is mainly expressed in the proximal and distal sections of the corpus region. HCR2 is weakly or not expressed in brain, lung, heart, spleen and testis. DCXR catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. DCXR participates in the uronate cycle of glucose metabolism. It may play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
25.6 kDa, under reducing conditions; 25.1 & 50.4 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
液体
储存缓冲液
PBS, 20% Glycerol, pH 7.4.
浓度
See COA
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
Store at -20°C for 1 year. Avoid freeze/thaw cycle.
图片
Recombinant Human DCXR Protein (rp188239) - SDS-PAGE 3 μg/lane of Recombinant Human DCXR Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 25.6 kDa under reducing conditions and 25.1 & 50.4 kDa under non-reducing conditions. DCXR is composed of approximately 26.0 kDa subunits and the X-ray crystal structure of human DCXR has been determined as a homodimer and the quaternary structure of the physiological tetramer was reported (PMID: 23988570).
ZJ25F0826338
危险品化学品经营许可证（带存储）