Carboxypeptidase A4, also known as CPA4, is a secreted, zinc-dependent metallocarboxypeptidase that removes the C-terminal amino acid from peptides having a free C-terminal carboxyl group. CPA4 can hydrolyze both amide and ester bonds and has a preference for cleavage at the amino side of hydrophobic residues. CPA4 is inhibited by latexin, an endogenous inhibitor of carboxypeptidases. The deduced amino acid sequence of human CPA4 consists of a signal peptide (residues 1-16), a pro region (17-113), and a mature chain (residues 114-421). The CPA4 gene has been associated with prostate cancer aggressiveness and is involved in the histone hyperacetylation signaling pathway. Recent studies show that coding variation in the CPA4 gene is linked to high-risk prostate cancer among younger patients.
48.1 kDa, under reducing conditions; 48.1 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from 20mM Tris, 150mM NaCl, pH 8.0
浓度
见COA
复溶
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 0.5 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
Store at -20°C for 1 year. Avoid freeze/thaw cycle.
图片
Recombinant Human Carboxypeptidase A4/CPA4 Protein (rp188298) - SDS-PAGE 3 μg/lane of Recombinant Human Carboxypeptidase A4/CPA4 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 48.1 kDa.
ZJ25F0319617
危险品化学品经营许可证（带存储）