Colorectal cancer suppressor | CRC18 | CRCR1 | DCC | deleted in colorectal cancer protein | deleted in colorectal carcinoma | IGDCC1colorectal tumor suppressor | Immunoglobulin superfamily DCC subclass member 1 | immunoglobulin superfamily, DCC subclass,
规格或纯度
无动物源,无载体,His标签,PBS Only,≥95%(SDS-PAGE),见COA
生化机理
Deleted in Colorectal Cancer (DCC) was originally identified as a putative tumor suppressor gene that is down-regulated in more than 70% of colorectal cancers (1). DCC is a type I transmembrane glycoprotein that belongs to the immunoglobulin (Ig) superfamily. It contains an extracellular domain (ECD) composed of four Ig-like domains and six fibronectin type III repeats, a transmembrane region, and a cytoplasmic domain. The ECD of human DCC shares 97% amino acid sequence identity with mouse and rat DCC. In adults, DCC is expressed most abundantly in brain tissue, but it is also expressed at low levels in multiple other tissues. DCC is a receptor for Netrin-1 and is important for dopaminergic neuronal precursor migration, axon guidance, and axon arborization. Binding of DCC by Draxin, at a site distinct from the Netrin-1 binding site, results in the inhibition of neurite outgrowth. Signaling downstream of DCC may also be required for the confinement of central axons to the central nervous system. DCC regulates apoptosis as a dependence receptor and induces apoptosis in the absence of Netrin-1 binding. DCC has been shown to inhibit metastasis, and loss of DCC’s apoptotic activity promotes tumorigenesis in mice, providing in vivo evidence that DCC is a tumor suppressor gene.
Post-translational: Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
127.1 kDa, under reducing conditions; 124.0 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from PBS, pH 7.4.
浓度
见COA
复溶
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
Store at -20°C for 1 year. Avoid freeze/thaw cycle.
图片
Recombinant Human DCC Protein (rp188303) - SDS-PAGE 3 μg/lane of Recombinant Human DCC Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 127.1 kDa under reducing conditions and 124.0 kDa under non-reducing conditions.
ZJ25F0420763
危险品化学品经营许可证（带存储）