Elo C | EloC | ELOC_HUMAN | Elongin 15 kDa subunit | Elongin C | Elongin-C | ElonginC | RNA polymerase II transcription factor SIII subunit C | SIII | SIII p15 | TCEB 1 | Transcription elongation factor B (SIII) polypeptide | Transcription elongation fact
规格或纯度
无载体,His标签,≥90%(SDS-PAGE),见COA
生化机理
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.
Post-translational: Ubiquitinated by the DCX(AMBRA1) complex, leading to its degradation by the proteasome.
Store at -20°C for 1 year. Avoid freeze/thaw cycle.
图片
Recombinant Human Elongin-C Protein (rp188313) - SDS-PAGE 2 μg/lane of Recombinant Human Elongin-C Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 12.3 kDa.
ZJ24F1216046
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