ERMAP | erythroblast membrane-associated protein (RD and SC blood groups) | erythroblast membrane-associated protein (Scianna blood group) | erythroblast membrane-associated protein | erythroid membrane-associated protein | hERMAP | MGC118810 | MGC118811
规格或纯度
无动物源,无载体,His标签,PBS Only,≥95%(SDS-PAGE),见COA
生化机理
Erythroid membrane-associated protein (ERMAP), also called Scianna blood group antigen, is a member of the butrophilin (BTN) and butrophilin-like (BTNL) family within the immunoglobulin superfamily. ERMAP consists of an extracellular domain (ECD) with one V-type Ig-like (IgV) fold, a transmembrane segment, and a cytoplasmic domain with a B30.2 motif. Within the ECD, human ERMAP shares 33% and 31% amino acid sequence identity with mouse and rat ERMAP, respectively. Interestingly, human ERMAP contains a single IgV-like domain in the ECD, while mouse and rat ERMAP contain both an IgV-like and IgC-like domain. However, the absence of the IgC-like domain in human ERMAP does not seem to affect its functions. ERMAP is an adhesion receptor molecule highly expressed in erythroid tissues, on the cell surface of resting and activated antigen-presenting cells (APCs) and in some tumor tissues. Fusion proteins (ERMAP-Ig) of both human and mouse ERMAP inhibit T cell functions in vitro and administration of the fusion protein ameliorates autoimmune diseases, including experimental autoimmune encephalomyelitis and type 1 diabetes, in mice. ERMAP acts as a novel inhibitory molecule for T cells and macrophages.
Post-translational: Glycosylated.
15.0 kDa, under reducing conditions; 15.2 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from PBS, pH 7.4.
浓度
见COA
复溶
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 0.5 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
-20℃保存 12个月；复溶后建议分装，避免反复冻融。
图片
Recombinant Human ERMAP Protein (rp188317) - SDS-PAGE 3 μg/lane of Recombinant Human ERMAP Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 15.0 kDa under reducing conditions and 15.2 kDa under non-reducing conditions.
ZJ25F0926719
危险品化学品经营许可证（带存储）