CDC37 is a protein that is expressed in proliferative zones during embryonic development and in adult tissues, consistent with a positive role in proliferation and is required for cell division in budding yeast. CDC37 is thought to play an important role in the establishment of signaling pathways controlling cell proliferation through targeting intrinsically unstable oncoprotein kinases such as Cdk-4, Raf-1, and src to the molecular chaperone Hsp90. Decreased Hsp90 expression can reduce the levels of microtubule-associated protein tau, whose overexpression may induce many diseases. CDC37 is considered as a co-chaperone that is classified as Hsp90's accessory proteins. It has been reported that suppression of Cdc37 destabilized tau, leading to its clearance, whereas cdc37 overexpression preserved tau.Cdc37 was found to co-localize with tau in neuronal cells and to physically interact with tau from human brain. Moreover, Cdc37 levels significantly increased with age.
Post-translational: Constitutively sumoylated by UBE2I.
生物活性
Immobilized Recombinant Human Cdc37 Protein (rp188343) at 1.0 μg/mL can bind Recombinant Cdc37 Antibody (Ab095626) with the EC50 of 2.5 ng/mL.
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
Store at -20℃ for 6 months. Upon reconstitution, it is recommended to aliquot. Avoid freeze/thaw cycle.
图片
Recombinant Human Cdc37 Protein (rp188343) - ELISA Immobilized Recombinant Human Cdc37 Protein (rp188343) at 1.0 μg/mL can bind Recombinant Cdc37 Antibody (Ab095626) with the EC50 of 2.5 ng/mL.
Recombinant Human Cdc37 Protein (rp188343) - SDS-PAGE 3 μg/lane of Recombinant Human Cdc37 Protein was resolved with SDS-PAGE under reducing (R) and visualized by Coomassie® Blue staining, showing a band at 45.0 kDa.