53 kDa putative calcium binding protein | 53 kDa putative calcium-binding protein | 53 kDa squamous epithelial induced stress protein | 53 kDa squamous epithelial-induced stress protein | 58 kDa heat shock protein | C1orf10 | Chromosome 1 open reading fra
规格或纯度
无载体,His标签,≥85%(SDS-PAGE),见COA
生化机理
CRNN is part of the "fused gene" family of proteins, which enclose N-terminus EF-hand domains and multiple tandem peptide repeats. CRNN contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. CRNN, also known as SEP53, which participates in the mucosal/epithelial immune response and epidermal differentiation. CRNN is a survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and discharge of calcium. When CRNN is over expressed in oral squamous carcinoma cell lines, it regulates negatively cell proliferation by the induction of G1 arrest. Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest.
Store at -20°C for 1 year. Avoid freeze/thaw cycle.
图片
Recombinant Human Cornulin Protein (rp188356) - SDS-PAGE 2 μg/lane of Recombinant Human Cornulin Protein was resolved with SDS-PAGE under reducing (R) and visualized by Coomassie® Blue staining, showing a band at 61.1 kDa under reducing conditions.
ZJ24F1215275
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