Ribosome-binding protein involved in ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with eiF5a (EIF5A and EIF5A2) at the polypeptide exit tunnel of the ribosome, preventing mRNA translation (By similarity).
Involved in ribosome hibernation in the mature oocyte by preventing mRNA translation, leading to ribosome inactivation (By similarity). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also acts as a negative regulator of autophagy (PubMed:20537536). Involved in mediating interferon-gamma-induced cell death (PubMed:7828849).
Post-translational: Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy.
Store at -20°C for 1 year. Avoid freeze/thaw cycle.
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Recombinant Human Amylin/DAP Protein (rp188367) - SDS-PAGE 3 μg/lane of Recombinant Human Amylin/DAP Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 15.4 kDa under reducing conditions and 15.2 kDa under non-reducing conditions.
ZJ25F0826147
危险品化学品经营许可证（带存储）