Grancalcin EF-hand calcium binding protein | GCL | Grancalcin penta-EF-hand protein
规格或纯度
无载体,≥95%(SDS-PAGE),expressed in E. coli; 见COA
生化机理
Grancalcin is calcium-binding protein which is particularly abundant in human neutrophils. GCA is a member of the penta EF-hand (PEF) subfamily of EF-hand proteins, who also comprises calpain, sorcin, peflin, and ALG-2. GCA undergoes essential conformational changes upon binding of calcium, which subsequently exposes hydrophobic amino acid residues, that direct the protein to hydrophobic surfaces. GCA cooperates with L-plastin, a protein known to have actin bundling activity, which suggests that GCA has a part in the regulation of neutrophils adhesion.
25.7 kDa, under reducing conditions; 25.7 & 48.5 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
液体
储存缓冲液
20mM Tris, 100mM NaCl, 20% Glycerol, pH 8.0;
浓度
expressed in E. coli; 见COA
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
-20℃（12个月）；收货后建议分装，避免反复冻融。
图片
Recombinant Human Grancalcin/GCA Protein (rp188393) - SDS-PAGE
3 μg/lane of Recombinant Human Grancalcin/GCA Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the bands at 25.7 kDa under reducing conditions and 25.7 & 48.5 kDa under non-reducing conditions.
It can form homodimers and interact with SRI and LCP1 (PMID: 11279160 PMID: 11717497 PMID: 12804766 PMID: 1530588).
危险品化学品经营许可证（带存储）