49 kDa TATA box binding protein interacting protein | 49 kDa TATA box-binding protein-interacting protein | 49 kDa TBP interacting protein | 49 kDa TBP-interacting protein | 54 kDa erythrocyte cytosolic protein | ECP-54 | ECP54 | ERYTHROCYTE CYTOSOLIC PRO
规格或纯度
无载体,生物活性,ActiBioPure™,His标签,≥90%(SDS-PAGE),见COA
生化机理
Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May be able to bind plasminogen at cell surface and enhance plasminogen activation. Essential for cell proliferation.
生物活性
Immobilized Recombinant Human RUVBL1 Protein (rp188428) at 1.0 μg/mL can bind TIP49A Antibody (Ab131386) with the EC50 of 118.7 ng/mL.
51.1 kDa, under reducing conditions; 50.0 & 124.3 & 214.7 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
液体
储存缓冲液
20mM Tris, 500mM NaCl, 10% Glycerol, pH 7.4
浓度
见COA
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
-20℃ 存储12个月；收货后建议分装，避免反复冻融。
图片
Recombinant Human RUVBL1 Protein (rp188428) - ELISA Immobilized Recombinant Human RUVBL1 Protein (rp188428) at 1.0 μg/mL can bind TIP49A Antibody (Ab131386) with the EC₅₀ of 118.7 ng/mL.
Recombinant Human RUVBL1 Protein (rp188428) - SDS-PAGE 3 μg/lane of Recombinant Human RUVBL1 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 51.1 kDa under reducing conditions and 50.0 & 124.3 & 214.7 kDa under non-reducing conditions. RUVBL1 can form a homohexameric ring and typically functions as a hexamer (PMID: 33205750).
ZJ25F0926923
危险品化学品经营许可证（带存储）