Cytidine deaminase (CDA) is an enzyme that scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. CDA is one of several deaminases responsible for maintaining the cellular pyrimidine pool. CDA also catalyzes the deamination of chemotherapeutic cytosine nucleoside analogs such as Ara-C and 5-azacytidine, which results in the loss of their cytotoxic and antitumor function. CDA can form homotetramers and is generally expressed in granulocytes. Mutations in the CDA gene are linked to decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
表达系统
E. coli
种属
人(Human)
氨基酸
2-146 aa
蛋白标签
N-His
无载体
Yes
无动物源
No
来源
重组表达
预测分子量
17.0 kDa
SDS-PAGE
15.1 kDa, under reducing conditions; 15.1 kDa, under non-reducing conditions.
Store at -20°C for 1 year. Avoid freeze/thaw cycle.
图片
Recombinant Human CDA Protein (rp188484) - SDS-PAGE 3 μg/lane of Recombinant Human CDA Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 15.1 kDa.
ZJ24F1215251
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