Beta 3 endonexin | Beta3 endonexin | Beta3 endonexin long form | CENP R | CENPR | CENPR_HUMAN | Centromere protein R | endonexin | Beta-3 | HSU37139 | Integrin beta 3 binding protein | Integrin beta 3 binding protein (beta3-endonexin) | NRIF 3 | NRIF3 | N
规格或纯度
无载体,His标签,≥90%(SDS-PAGE),见COA
生化机理
Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
20mM Tris, 240 mM NaCl, 0.75M Urea, 10% Glycerol, 1 mM EDTA, 0.1 mM DTT, pH 8.0
浓度
见COA
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
-20℃ 存储6个月；收货后建议分装，避免反复冻融。
图片
Recombinant Human ITGB3BP Protein (rp188502) - SDS-PAGE 3 μg/lane of Recombinant Human ITGB3BP Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 26.7 & 50.6 & 92.3 kDa under reducing conditions and 24.6 & 26.4 & 45.6 & 47.1 & 52.7 & 74.1 & 107.7 kDa under non-reducing conditions. ITGBPBP can form Homodimer. Multiple bands of ITGB3BP correspond to various phosphorylation conformations under non-reducing conditions (Uniprot: Q13352; PMID: 36069839).
危险品化学品经营许可证（带存储）