CFIM 25 | CFIM25 | Cleavage and polyadenylation specific factor 5 | Cleavage and polyadenylation specific factor 5 25 kD subunit | Cleavage and polyadenylation specific factor 5 25 kDa | Cleavage and polyadenylation specificity factor 25 kDa subunit | Cle
规格或纯度
无载体,His标签,≥95%(SDS-PAGE),See COA
生化机理
Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export.
Post-translational: Acetylated mainly by p300/CBP, recruited to the complex by CPSF6. Acetylation decreases interaction with PAPAO. Deacetylated by the class I/II HDACs, HDAC1, HDAC3 and HDAC10, and by the class III HDACs, SIRT1 and SIRT2.
Store at -20°C for 1 year. Avoid freeze/thaw cycle.
图片
Recombinant Human NUDT21/CFIM25 Protein (rp188503) - SDS-PAGE 3 μg/lane of Recombinant Human NUDT21/CFIM25 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 26.5 kDa.
ZJ25F0420887
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