DUBA-8 | DUBA8 | HIN-7 | HIV-1-induced protease 7 | HsHIN7 | OTU domain containing 2 | OTU domain-containing protein 2 | OTU1_HUMAN | OTUD2 | PRO0907 | RP11-164O23.1 | Ubiquitin thioesterase OTU1 | yod1 | YOD1 OTU deubiquinating enzyme 1 homolog (S. cerev
规格或纯度
无载体,His标签,≥95%(SDS-PAGE),见COA
生化机理
Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation (PubMed:27753622).
Store at -20°C for 1 year. Avoid freeze/thaw cycle.
图片
Recombinant Human YOD1 Protein (rp188513) - SDS-PAGE 3 μg/lane of Recombinant Human YOD1 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 42.1 kDa under reducing conditions and 42.2 kDa under non-reducing conditions.
ZJ25F0319163
危险品化学品经营许可证（带存储）