CASQ2 belongs to the calsequestrin family and is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. CASQ2 is a calcium binding protein that stores calcium for muscle function. The discharge of calcium bound to CASQ2 through a calcium release channel activates muscle contraction. CASQ2 binds 40 to 50 moles of calcium. CASQ2 mutations result in stress-induced polymorphic ventricular tachycardia, also called catecholaminergic polymorphic ventricular tachycardia 2 which is known fir its bidirectional ventricular tachycardia that causes cardiac arrest.
Post-translational: Phosphorylation in the C-terminus, probably by CK2, moderately increases calcium buffering capacity.N-glycosylated.
Store at -20℃ long term (12 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
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Recombinant Human CASQ2 Protein (rp189286) - SDS-PAGE
3 μg/lane of Recombinant Human CASQ2 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the bands at 47.1 kDa under reducing conditions and 47.1 & 95.1 kDa under non-reducing conditions.
CASQ2 can form homodimers and homooligomers, mostly monomeric in the absence of calcium (PMID: 21416293).
ZJ26F0131699
危险品化学品经营许可证（带存储）