CDK2-associated protein 1 | cyclin-dependent kinase 2-associated protein 1 | CDKAP1 | cyclin-dependent kinase 2 associated protein 1 | Deleted in oral cancer 1 | Deleted in oral cancer-1 | DOC-1 | DOC1 | Putative oral cancer suppressor | DORC1 | p12DOC-1
规格或纯度
无载体,His标签,≥95%(SDS-PAGE),见COA
生化机理
CDK2AP1 is a specific CDK2-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. Also, interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggested the regulatory role in DNA replication during S phase of the cell cycle. A similar gene in hamster was isolated from, and functions as a growth suppressor of normal keratinocytes.
Post-translational: Phosphorylated in vitro by IKBKE at Ser-46.